EDITORIAL. 
371 
In May the reaction failed to appear in any of them, and 
from that date to July, when four of these horses were killed,, 
when three, four and five months had elapsed, if the reaction 
is absent, if no elevation of temperature, no swelling at the point 
of inoculation are observed, after the evidence of the presence 
of the disease, inoculated through the digestive canal, has been 
so conclusively demonstrated by the malleine test, it is, said Prof. 
Nocard, “ because the animals have recovered—they are cured.'^'^ 
Four of the six animals were destroyed, and post-mortems 
made before the greatly interested crowd of scientists who had 
listened to the history of the whole experiment as related by 
Prof. Nocard. 
In all the lungs were found : miliary tubercles in their vari¬ 
ous forms—caseous, calcareous ; some translucid tubercles ; some 
small spots of lobular broncho-pneumonia ; but no other lesions 
of glanders, either in the trachea or anywhere else. In fact, the 
lesions were very much similar to those that one meets with in 
the lungs of those peculiar forms of latent diseases, in pulmo- 
nary glanders. But these macroscopic lesions were those of 
contagious glanders only in appearance, to the naked eye ; they 
were not otherwise ; they were dead lesions, so to speak ; the 
bacillus was no longer present, and the evidence of it was given 
by a supplementary experiment. 
Most of these lesions, miliary, caseous, calcareous, translucid 
tubercles, with pieces of lungs showing lesions of broncho-pneu¬ 
monia (the nature of which was not certain), were collected, 
put into a china mortar, and crushed thoroughly with a small 
quantity of bouillon, to be inoculated by Dr. Roux to female 
donkeys and guinea-pigs, both typical subjects for such investi¬ 
gations. In all of them the results were negative, with the ex¬ 
ception of a local abscess at the point of inoculation ; the don¬ 
keys did not develop glanders ; the guinea-pigs did not have the 
characteristic orchitis of glanders. 
* 
From this interesting experiment some very important facts 
impose themselves : 
