454 
E. NOCARD. 
degrees, and the whole solution injected at once; for horses, 
venous injections are preferable ; the serum acts more completely 
and more rapidly ; 24 hours are gained over the subcutaneous 
injection. For man, also, the intravenous injection is prefer¬ 
able. 
“ If the injection is made under the skin, success cannot be 
expected, in acute cases, only if interference has been applied dur¬ 
ing the 36 first hours after the appearance of tetanus. On that 
account this remedy must be kept in stores, in large hospitals, 
and veterinary institutions. The manufacturers send the cura¬ 
tive dose, and it is inexpensive ; it is sold at 30 marks (over 
seven dollars), a very moderate price, considering the efficacity 
of the product ” 
Since the publication of the Dent, Med. WochenscMift^ Ger¬ 
man veterinary papers have recorded a certain number of obser¬ 
vations concerning tetanic horses treated by the antitoxin from 
Hochst. The number of successes obtained has not reached 
half of the cases treated ; and yet all failures are not known ; I 
know, for instance, that at the Veterinary Institute of Budapest 
three tetanic horses were treated and died. My colleague. Prof. 
Cadiot, of Alfort, has not been more fortunate with two cases, 
where the disease did not seem exceptionally severe. 
The results in practice do not appear to confirm the prom¬ 
ises of the Detit. Med. IVochenschrift. I know well that the 
conditions in practice do not very well allow of judgment in 
such matters. Most commonly, the veterinarian is consulted 
late, several days after the appearance of the first symptoms; 
the failure of treatment may be due to this late application in 
the interference;—and, again, when the tetanic horse recovers 
after the injection of serum, who can tell if he would not have 
gotten well without it? On one side, as on the other, there 
are probabilities; certainty is wanted ; all that careful study of 
the published observations permit us to observe is that in 
promising success “ when the injection will be made in the 
thirty-six hours following the appearance of tetanus” the author 
* If our memory is correct, the French dose costs 0 , 25 . 
