SEROTHERAPY OF TETANUS. 
461 
serum, one hour after the inoculation of toxin ; he never pre¬ 
sented the slightest symptom. 
No. 49,298 (Norman) received under the skin 20 c.c. of same 
serum twenty-four hours after the injection of toxin. This one 
has not shown any signs of illness. 
54537^ (Danish) received under the skin 30 c.c. of serum, 
forty-eight hours after the toxin ; some stiffness and curvature 
of the neck existed on the 19th of March, it lasted some two 
weeks ; but the animal kept eating, was gay and his legs sup¬ 
ple ; he never was very ill; recovery took place rapidly. 
No. 60,277 (Hungarian) received under the skin (March 
12th) three cays after the injection of toxin 40 c.c. of serum. 
In the morning of March 14th, he was certainly tetanic ; the 
same day at 10 o’clock he was injected in the jugular with 
75 c.c. of serum ; until March 25, the disease went on progress¬ 
ing, and then gradually diminished to such degree that on 
April 4th everything was normal with him, except a marked 
curvature of the neck, on the side where the toxin had been 
injected. 
If the extreme severity of this experiment is taken in con¬ 
sideration—viz., the dose of toxin, always fatal to witness, hav¬ 
ing been injected all at once and immediately absorbed, one 
can affirm that, in daily practice, there will be a great many 
chances to arrest the evolution of tetanus or to prevent its ap¬ 
pearance, by interfering even several days after the traumatism. 
But one must well know that the more the interference is de¬ 
layed, the greater the dose of serum to inject must be. 
* 
* H; 
From this long experimental study, I believe I am right in 
concluding, as I did in 1895, that the curative treatment of 
tetanus is yet to be found. 
This does not mean that the use of antitoxic serum in the 
treatment of confirmed tetanus must be abandoned. 
Far from it ! It is my deep belief that the injection of serum 
is the best mode of treatment that one can employ. Indeed, all 
those of my colleagues that have treated tetanic horses by injec- 
