FOOT-AND-MOUTH DISEASE. 
631 
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iilent blood on one side of the animal and immediately after 5, 
10, 20 c.c. of serum on the other side. The animal thus 
treated suffers from a modified form of the disease, and is salted. 
The following table gives the result of an experiment made up¬ 
on 29 animals: 
No. of Animals. Dose of Serum. No. died. 
11 20 c.c. I 
12 10 c.c. 8 
6 5 c.c. 6 
“ In regard to the treatment of herds already inoculated with 
Koch’s bile, and in which the disease usually, although not in¬ 
variably, appears again after a short time, Drs. Turner and 
Kolle state that these beasts respond readily to the action of 
serum, but that they must be sick at the time the serum is in¬ 
jected, otherwise they do not salt.” 
FOOT-AND-MOUTH DISEASE. 
Loeffler and Frosch (^Deittsche Medicmische WochenschiHft^ 
September 23, 1897, p. 617), constituting a commission appointed 
to investigate foot-and-mouth disease, report the following sum¬ 
mary of the conclusions reached by them : (i) All of the 
bacteria hitherto described as the exciting cause of this disease 
have been accidental associations. The disease can be induced 
by inoculation with sterile lymph obtained from the vesicles, 
which contains morphotic elements of various kind. Protozoa 
have not been demonstrated as the causative agents. (2) Beef 
and swine have been also shown experimentally to be especially 
susceptible to the disease. Sheep and goats could not be 
infected artificially at first, as well as dogs, rabbits, guinea-pigs, 
ordinary mice, field-mice, and fowl. (3) The most certain 
mode of infection consists in the injection into the circulation 
of lymph obtained from vesicles. Infection could be induced 
also by injection of -such lymph into the abdominal cavity and 
into the muscles, as well as by its introduction into the mucous 
■ membrane of the mouth previously injured by puncture. 
! Uncertain results followed subcutaneous and cutaneous inocula- 
i tion. In animals inoculated by intravenous injection vesicles 
1 appeared first in the mouth, and in milch cows upon the udders, 
after the lapse of from one to three days—in accordance with 
the amount and virulence of the lymph—in conjunction with 
febrile manifestations, and one or two days later vesicles 
appeared, first upon the extremities. Both sets of vesicles are 
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