summers of ’87 and ’88. When speaking of his journeys 
through the country, he says : ‘'I was unable to find a single 
animal with symptoms answering to those ascribed to this 
weed. Among the few I found suspected of this distemper 
was one of a herd from Indian Territory, just south of Arkansas 
City, brought from Texas for pasture. When informed of the 
case, I was very eager to avail myself of the opportunity, and 
at once went to the ranch. But on inspecting the animal was 
very much disappointed to find no symptoms corresponding 
with my expectations of an ideal locoed animal. On the con¬ 
trary, the creature was affected with some loathsome disease 
combined with very old age. 
“In the summer of ’87, I had a good opportunity to kill and 
make post-mortem examination of a cow said to have been 
eating the weed for two years, and which was given to me as 
an example of an animal possessed of the loco habit. She 
was four years old, though no larger than at two years. The 
loco had not only stopped her growth, but made her quite 
poor, and gave her a wasted appearance. She seemed stupid, 
debilitated, unsteady in her movements, the breathing short 
and rapid, with muscular force ver}/much impaired. Whether 
walking or standing, it was seemingly beyond her power to so 
control the muscles as to keep her head perfectl}/ still. Her 
eyes had exhibited a wild stare, so said, but this had recently 
disappeared. 
POST-MORTEM. 
“The blood was light but not normal; having no instru¬ 
ment at hand it was not microscopically examined. The 
paunch was in a normal condition ; the reticulum and psalter- 
ium softened, and apparently diseased. Throughout the en¬ 
tire length of the intestines there seemed to be degeneration 
of tissue, being on the inside peculiarly soft. Two or three 
perforations were observed in the small intestine. Both the 
large and small intestines were delicate, devoid of elasticity, 
and even with most careful handling would be torn or broken 
apart in places ; they appeared to be as one expressed it, rot¬ 
ten in spots. The peritoneum and omentum were inflamed, 
and presented numerous tumors about the size of a pea, fleshy 
in appearance and of fibrous nature. The pleura appeared 
normal, as also did the diaphragm. The pericardium was 
streaked with red on the inner side, the sac containing about 
a pint of liquid of a pale color. The heart seemed to be about 
one third larger than the normal. The mitral and tricuspid 
valves were inflamed around the edges. The valves of the 
aorta appeared normal, and just above them the serous coat 
