lO 
have, however, afforded us the conviction that both the Astra¬ 
galus and the Crotalaria contain very small amounts of toxic 
alkaloids, to which we believe the symptons of poisoning pro¬ 
duced by these plants may reasonably be attributed. It is 
only to be regretted that these alkaloids, as well as most of 
the other constituents of the plants, are of such a character 
as not to render their further .chemical study specially allur- 
mg. 
In the report of the Veterinary Department of the State Ag¬ 
ricultural College, by Dr. Faville, issued in January, 1885, page 
i^, he says : “ With a view of determining the symptons and 
post iJiovtcm appearances of the disease, (during the month of 
August,) President Ingersoll, of the college, visited the ranch 
of Hon. J. M. Givens, of El Paso county, who set aside for 
his experiments, a number of sheep that were “ locoed.” I 
append the report of the President, made to me upon his re¬ 
turn from the investigation. He found the animals showing 
a very great degree of emaciation, and also showing to its 
greatest degree, the loco habit. They would wander about 
in an aimless way, refusing all other food except the loco. 
President Ingersoll made several post jnortem examinations, 
and found the same condition of things that I shall describe 
further on. As an experiment he tried the effect of feeding 
the loco. A young lamb about two months old, that was 
being raised on a bottle, was selected. Twenty pounds of 
loco were cut just below the crown, and that contained no 
seed ; in other words, just the portion that the sheep were 
getting to eat. This was placed in a wash boiler, in seven or 
eight gallons of water, covered tightly, and boiled for twelve 
hours. The juice was then expressed and evaporated to the 
volume of one quart, when it was a thick syrup, with a smell 
and taste much like glucose. This was then given to the lamb 
instead of milk, being fed from the bottle, just as the milk 
had been. It was given as follows : Seven tablespoonfuls at 
4:30 p. m.; four tablespoonfuls at 5:30 p. m.; four tablespoon¬ 
fuls at 7 p. m. The next morning the bowels were slightly 
loosened, but nothing more could be seen. The next day 
two tablespoonfuls were given at 6 a. m.; four tablespoonfuls 
at 7 a. m.; six tablespoonfuls at 12 m.; two tablespoonfuls at 
1:30 p. m.; four tablespoonfuls at 6 p. m. The next morning 
two tablespoonfuls at 6 a. m.; four tablespoonfuls at 12 m., 
making thirty-nine tablespoonfuls that were given, in the 
place of the regular allowance of milk, and which constituted 
all the food it got for forty-three and one-half hours. There 
were no deleterious effects, that could be noticed, and I saw 
and very carefully examined the lamb, about two weeks after- 
