13 
showed a greater craziness. The whole system was so run 
down that, in running and throwing himself, he bled profusely 
at the nose. The unsteadiness and emaciation were the 
same as in the first case. The post mortejn symptoms were 
the same, a .description of one answering for the other. I 
had the brain from this case photographed and a cut made 
of it, which is appended.” 
Dr. Faville’s conclusion was that the loco contained some 
poisonous principle ‘That caused a hemorrhagic effusion into 
the base of the brain, causing symptoms of craziness and loss 
of muscular control.” During the fall of 1889, Dr. McEckran, 
then of the college, instituted the experiment of feeding the 
loco to an animal, the property of Hon. B. S. LaGrange, a 
member of the State Board of Agriculture. I have not 
been able to obtain the record of the experiment, and can 
only state the general plan and the conclusion of the experi¬ 
ment. The animal was placed in a stable and the loco {As¬ 
tragalus Mollissimtcs and Oxytropis Lamberti) was cut up fine, 
and mixed with other food so the animal would eat it. This 
feeding was continued about two months with no symptoms 
of the so-called loco disease. 
Enough has been given of the history of the loco and also 
of the symptoms by which the animals are affected. I have 
made many inquiries of those that stated they had any exper¬ 
ience with the ioco or locoed animals. 
Binford & Spencer, 
COAL DEALERS, 
Denver, Colo., September 27, 1890. 
D. O'Brine, Professor Chemistry, Tlgriculiural College, Fort Collins, Colo.: 
Dear Sir. —You will please excuse my apparent neglect in not complying with 
your request sooner, in giving you my experience with the loco weed in New Mex¬ 
ico. The summer of ’81 was the most disastrous to stockmen that to my knowl¬ 
edge has ever occured in that Territory, and probably the cattle in Ute Creek Val¬ 
ley suffered more than those on other streams. The loco weed was that bearing 
purple and white flowers ; the conditions were, dry weather and short grass. The 
stock ate freely of the weed, and at any time one could see horses and cattle in all 
stages of the disease, caused by eating thereof. The rough examination that we 
were able to give the stock which died, showed the stomach and sometimes por¬ 
tions of what is commonly called the manifold, to be lined and perforated by a 
small parasite, 
A certain druggist in Springer, whose name 1 cannot recall, had a fair micro- 
scDpe. This we used in examining the plant. We found that almost every plant 
had one or more leaves that were rolled, indicating that some worm or bug had 
been at work on it. These leaves, on being unrolled, contained a very small, white 
parasite. I cannot say that the two, that is the parasite in the stomach and the 
one in the leaf, had much resemblance to each other, in fact, rather the con¬ 
trary. But this, if our theory is true, might be due to the growth of the insect. 
It was the common opinion of those of us who were investigating this matter, that 
