THE MICROBE OF PLEURO-PNEUMONIA. 
391 
No. /.—Cow, 3 years old, calved Feb. 23, inoculated Feb. 26, 1898, 
with 10 drops of a fifth culture, m vitro (10 days incubation)! 
rapidly during the following days, it extends under the shoul¬ 
der, pushes it from the trnnk and stiffens the leg. On the iith 
the temperature is abont 40° C., and remains at this point until 
death. It reaches 4o.7°C. on March 13th. At the same time the 
swelling increases in all directions, to the dewlap, where it forms 
a tumor as big as a child’s head, nnder the abdomen, where it 
forms an oedematons swelling as thick as the arm, and back to 
the ndder; the milky secretion has diminished, the appetite is 
gone, the animal loses, flesh, rnmination remains, but is slow 
and irregnlar. 
^larch 17th, swelling is enormons, the animal carries no 
more weight on the left anterior leg, the arm and forearm is 
largely swollen, any movement is impossible. 
March i8th, the animal is stretched on the bedding, unable 
to rise. She dies on the 19th, towards 2 o’clock p. m., with 
hypothermia (37.8°). 
Post-mortem .—In removing the skin an enormous quantity 
of citrine and transparent serosity escapes. The subcutaneous 
tissue is the seat of a large infiltration which in some points is 
more than 10 centimeters thick ; the exudation occupies all the 
