GLANDERS AND ITS SUPPRESSION. 
653 
Farcy .—Farcy may be produced by cutaneous infection in 
various ways, such as wounds, abrasions, hypodermically and by 
glanderous material being placed upon the skin or mucous 
membrane. If on the skin it will be necessary to apply friction, 
or to thoroughly rub it into the openings of the same. Ninety 
per cent, of all'cases of farcy are produced by the bacilli escap¬ 
ing from the lungs or through them, gaining entrance into the 
general arterial circulation, in which it is carried to the extrem¬ 
ity of the artery, into the capillary system, where the bacilli es¬ 
cape from these small vessels into the small tissue spaces and 
smaller lymphatics. When they have once gained entrance 
into these tissue spaces they are permitted to remain at rest for 
a longer or shorter period of time, thus giving them ample op¬ 
portunity (if not destroyed by nature’s elements) to multiply 
and produce their characteristic lesions. And if such lodgment 
and development should be near the surface of the body there 
would be manifest farcy buds. I am supported in this state¬ 
ment by the fact that farcy buds may be seen on different parts 
of the body almost simultaneously, which would not take place 
if they were produced by cutaneous infection. 
Mallein was first produced by Kalning, Preusse and Pearson, 
by making a culture of the bacilli of glanders in the proper cul¬ 
ture media. I consider it of great value as an assisting agent in 
making diagnoses in occult cases. In fact, I have never known 
it to fail in the work for which it is intended. I have used it 
on more than two thousand horses, which were diseased or had 
been exposed. I have used mallein experimentally to test its 
value as a diagnostic agent on 138 healthy horses, of all ages, 
at all seasons of the year. On six horses with well marked 
generalized melanosis, thirteen cases of pleurisy, sixteen cases 
of pneumonia, three cases of pleuro-pneumonia, twenty-four 
cases of influenza, three cases of purpura hsemorrhagica and 
fourteen cases of lymphangitis, two of which were in a state of 
suppuration ; i. e.^ having numerous little abscesses from the 
hoof to the stifle, resembling very much the buttons and ulcers 
of farcy. None of these animals showed the slightest degree of 
