GLANDERS AND ITS SUPPRESSION. 
655 
that some of the animals may not react until late in the day. 
I have in one instance observed an animal that did not show 
the slightest disturbance until twenty-three and a half hours 
had passed after the injection of mallein, and at the expiration 
of this time he commenced to react to an extreme degree, and 
the disturbance was so great that he died at the end of the 
fourth day. Post-mortem showed the lungs to be in a desper¬ 
ate glanderous condition, with the liver badly affected. 
In a number of instances I have observed that the animals 
have not shown any indication of reaction until eighteen, 
twenty, twenty-one and twenty-two hours have passed, while 
all experimenters know the reaction will usually be manifest at 
a period ranging from eight to fifteen hours. 
All animals that show an elevation of temperature of four 
or more degrees, have a large and painful swelling at the point 
of injection, excessive systemic disturbance, loss of appetite 
and depression, should be destroyed at once. 
All animals showing an elevation of temperature of two or 
more degrees, with a moderate amount of swelling at the point 
of injection, no noticeable amount of depression, no loss of 
appetite and systemic disturbance, except the elevation of tem¬ 
perature, should be isolated and kept from all other horses, 
under quarantine for from three to six months and inspected 
once each week by a competent veterinary surgeon. They 
should be out in the open air and sunshine, with moderate 
work, but never enough to produce exhaustion ; at the end of 
this period they should be given another mallein test. All 
animals showing reaction at the last test should be destroyed, 
and those which do not should be released from quarantine. 
All animals not showing reaction at first test can be released 
from quarantine as healthy. 
The Use of Mallein as a Therapeutic Agent .—It is claimed 
by some very eminent men that mallein will cure occult glan¬ 
ders. Is it not possible mallein is given credit for doing what 
nature has done ? Tet us look at the question for a moment. 
As I have already said, an average of forty per cent, of all ani- 
