656 
J. M. WRIGHT. 
mals exposed are infected with the virus of glanders. If these be 
kept at moderate work, out in the open air and sunshine and be 
housed in pure, clean, well-ventilated barns with plenty of good, 
pure water and nourishing food, less than five per cent, of the 
forty per cent, will develop into clinical glanders, but will be¬ 
come free of the infection. In such cases if mallein were used 
it would be given the credit. 
I have been unable, by the use of mallein as a therapeutical 
agent, to determine the percentage of developments into clinical 
cases, or to diminish the number of mortalities, although I have 
noticed emaciated animals, after its use, apparently improve in 
flesh, and occasionally they will continue to improve for three, 
four and five months, and then develop into clinical cases of 
glanders. I have given doses every seven days, but found that 
after four or five doses there would be no reaction, as far as ele¬ 
vation of temperature is concerned, but a part of them would 
develop into clinical cases. I have tried to accomplish the de¬ 
sired end by giving a dose every thirty days, and with others 
every sixty days, but the results were negative and some of 
them would develop into clinical cases. In all these animals 
the treatment was the same as that given those which slightly 
reacted from the test. 
d^aking all these facts into consideration, I do not feel justi¬ 
fied in recommending the use of mallein as a curative agent, 
except experimentally, fearing that inexperienced persons may 
release animals from quarantine that should be held. 
ScimtcLtioH. Before beginning the fight with this enemy it 
will be well for us to have some knowledge of its power of re¬ 
sistance. First, we find the true cause of this disease is a bacil¬ 
lus, slightly shorter and decidedly thicker than the bacillus of 
tuberculosis, rounded at the ends and slightly curved upon itself. 
It can be cultured in various culture media. Outside the body 
it will develop in the proper media at a temperature above 
68 F. and below 113° F. At a temperature above 113° F. or 
below 68 ° F. its growth is arrested and it soon perishes. It is 
destroyed in a temperature of 145° iii ten minutes, and in a 
