PARAPLEGIA IN THE HORSE. 
739 
While collecting this fluid, I had found in it very fine 
granulations, which through the microscope I made out to be 
little masses of streptococci. The quantity of these microbian 
erannlations was such that I was actuated with the idea of their 
possible specificity. I then studied this streptococcus to the 
point of view of its properties of culture and its pathogenous 
action. I was at that time beginning the comparative study of 
the streptococci, not only of this one, but also of those of ana¬ 
sarca, and it was only towards the end of 1895, and specially at 
the beginning of 1896, that it became possible to me to make 
known the first results of my observations. 
The streptococcus found in the paraplegic horse is of the 
strangles kind, aerobic and anaerobic ; it takes the Gram well. 
In bouillons, it grows specially in tufts, which settle in deposit 
at the bottom of the tube and give to the media an acid reaction. 
It coagulates milk ; does not grow on potatoes ; on peptoned 
gelose, small round colonies of greyish white color are devel¬ 
oped. Gelatine is not a very favorite media, microbes multiply 
without liquefying it; they form a very delicate whitish dott¬ 
ing. Serum gives colonies, flatter and somewhat wider than 
on gelose. The microbe develops quite well in bouillon of 
serum. 
INOCUI.AT10NS. 
I might here repeat all that is already known of the strep¬ 
tococcus of Schiitz, but I go on rapidly to insist a little upon 
two peculiarities relating to the inoculation on mice and on 
horses. 
Carnivora, swine, ruminants and birds resist experimental 
infection. The guinea-pig and rabbit resist well subcutaneous 
inoculations, but the former succumb to intra-peritoneal and the 
latter to intravenous injection. On the contrary, mice are very 
sensitive and die, even with subcutaneous injection of a small 
dose (two or three drops of culture). 
Peritoneal inoculation is peculiarly fatal, and, as an inter¬ 
esting fact, produces a highly acute parenchymatous nephritis 
with strongly bloody urine. As very few microbes are found in 
