PARAPLEGIA IN THE HORSE. 
743 
In mice, intraperitoneal inoculation sel¬ 
dom gives bloody urine. 
Subcutaneous inoculation on white mice 
is frequently fatal ; at the point of inocula¬ 
tion the pus is not very abundant and the 
spleen is slightly hypertrophied. 
The rabbit is generally sensitive to sub¬ 
cutaneous inoculation ; after death the 
spleen is markedly hypertrophied. 
Colts support subcutaneous injection 
well. 
Influenced by the antistreptococci serum 
originary from the streptococcus pyogenes. 
In mice, the same inoculation produces 
more easily bloody urine. 
The same inoculation on the same 
animal is much more serious than with the 
streptococcus pyogenes ; at the point of in¬ 
oculation,, there is a great deal of pus and 
the spleen is enormous. 
Rabbit is little sensitive to subcutaneous 
inoculation and when it dies, the spleen is 
about normal. 
Colts react well—subcutaneous inocula¬ 
tions, specially to the chest, produce an 
enormous phlegmon which ends in an ab¬ 
scess very rich in homogeneous white pus, 
creamy, where long rods taking the Gram 
are found in great quantity. 
Not influenced by the sa,me. 
CONCLUSIONS. 
Evidently paraplegia of the horse, as that of man, may have 
nnmerons causes. For instance, it is certain that typhoid fever 
of solipeds is sometimes followed by paralysis. I have, in fact, 
observed an epizootic outbreak, which had no other cause. 
This complication is, however, easily understood, as long as the 
organism of typical patients is almost always invaded by vari¬ 
ous streptococci. 
But outside of epizootic paraplegia, my researches seem to 
prove the important, if not specific, part played in the etiology 
of the classical disease by the streptococci which pullulate in the 
subarachnoid and the cephalo-rachidian fluids, thus explaining 
well the paraplegic phenomena. As for haemoglobinDemia, its 
pathogeny is a little more difficult to understand, and for the 
present I do not wish to advance any supposition. 
This new idea, which, however, only pro vise the microbian 
theory, has nothing to upset the facts obtained by observation. 
It is thus that plethora, return to work after a certain rest, and 
specially cold, remain always predisposing causes of the first 
order. 
The streptococcus may exist in the organism without awak- 
