SOME NEW VETERINARY DRUGS. 
587 
satisfactory results in long haired animals, it is necessary to 
apply the solution with a strong stiff brush, so as to ensure 
forcing it through to the skin. 
COIylyARGOIyUM—ARGENTUM COLUOIDARE CREDE. 
Argentuvi Solubile Crede—Sohible Metallic Silver Crede. 
Prepared at the Chemical Factory Von He}^den at Radebeul, near Dres¬ 
den, Germany, after the process of Prof. Crede. 
Collargolum is a non-toxic, allotropic silver, occurring in 
commerce as brownish-black, lustrous, irregular, fragile lumps, 
of neutral reaction, and readily soluble in water and albuminous 
fluids. According to Crede it remains as metallic silver in 
sterile blood or lymph, but when in the presence of pathogenic 
bacteria or their toxins, enters into combination and acts as a 
powerful germicide or antitoxic agent. In veterinary practice 
it may be regarded as a specific in the treatment of purpura of 
the horse and can be safely administered in very large doses, as 
argyria does not appear to result from its use. 
It has been proposed as a diagnostic agent to detect glan¬ 
ders in the horse, but in this it fails entirely. In purpura, I 
have found that this form of silver, when administered subcu¬ 
taneously or per os, is of little or no use, but very prompt re¬ 
sults follow the intravenous injection of this agent. The best 
form for this purpose is a solution of 0.5 (7% grs.) in 50 cc. of 
sterile water to be thrown directly into the jugular vein ; these 
injections are made three to five times daily ; in fact, Prof. 
Dieckerhoff has used it as frequently as every two hours during 
the first day. It is a fact that in all of my cases treated with 
collargolum the petechise disappeared in a day or two at the 
most, while the swellings were more persistent, and while these 
were considerably abated, they did not disappear entirely for 
several days. Some cases received as many as 22 intravenous 
injections without any bad results ; in fact, I have not lost a 
case of purpura since I began treating this disease with col¬ 
largolum, which I push till the petechise and swelling disap¬ 
pear. When very frequent injections are administered, the 
faeces become blackened. Local applications, consisting of salt 
