ANTISEPTIC THERAPEUTICS. 
741 
space containing only a small amount of granular detritus. In 
some cases there was evidence of repair shown by the presence 
of young connective tissue cells around the necrotic fibres. In 
the psoas of the one case of pneumonia examined the same ap¬ 
peal ance of degeneration was seen, and was there rather more 
intense than that observed in any of the azoturia series. 
Summary .—In the eleven cases of azoturia examined changes 
were found in the liver, spleen, kidney, and psoas muscle. The 
lesions were : 
Fatty degeneration of the liver. (Five cases.) 
Focal necrosis in the liver. (Four cases.) 
Proliferation of the epithelioid cells in the lymph follicles 
of the spleen. (Three cases.) 
Haemorrhagic infarcts in the spleen. (Two cases.) 
Pigmentation of the spleen. (Seven cases.) 
Parenchymatous degeneration of the psoas muscle. (Nine 
cases.) 
Acute parenchymatous degeneration of the kidney. (Ten 
cases.) 
Chronic interstitial nephritis. (Fight cases.) 
Conclusions. —(i) The acute degenerations of the liver and 
kidney, the proliferation of epithelioid cells in lymph follicles 
of the spleen, and the focal necroses in the liver are similar to 
lesions found in man during various of the acute infectious dis¬ 
eases. In the case of the human being such changes are gener¬ 
ally regarded as manifestations of a toxaemia. 
(2) The pigmentation of the spleen indicates nothing more 
than a destruction of blood corpuscles, and is common to a num¬ 
ber of diseases in both man and animals. 
(3) The degeneration of the psoas muscle is quite analogous 
to the Zenker’s degeneration seen in typhoid fever. 
(4) The chronic interstitial nephritis would indicate either 
that some toxic substance had acted for a considerable time, or 
that there had been previous attacks of an acute nature. 
We have, then, the picture of a pathological process com¬ 
bining chronic and acute factors. This condition seems most 
