PHYSIOLOGICAL EXPERIMENTS ON ARECOLINE HYDROBROMATE. 27 
muscular trembling, with elevation of the tail. These symptoms re¬ 
mained for an hour with frequent manifestations of pain by uneasiness. 
i hour. All symptoms had abated. No local inflammation at point 
of injection. 
III. —EQUINE. 
This was an aged sound horse weighing ten hundred and fifty 
pounds, in good condition. 
Administered twenty milligrammes subcutaneously. 
Normal pulse, 54; temperature, 101.1; respiration, 7. 
4 minutes. Marked salivation. 
10 minutes. Diuresis. 
15 minutes. Pulse, 50; temperature, 101 ; respiration, 12 ; frequent 
and loud borborygmi in left hypochondriac region. 
25 minutes. Liquid evacuation ; respiration becoming very labored 
at this time, marked secretion from nasal passage. 
30 minutes. Salivation had ceased, but abdominal pains and efforts 
at micturition were manifest. 
1 hour. The physiologic symptoms had passed away. No local in¬ 
flammation at point of injection. 
IV. —EQUINE. 
This was an aged bay horse in thriving condition, weighing 
about one thousand pounds. 
Administered thirty-five milligrammes intravenously. 
Normal pulse, 54; temperature, 101 ; respiration, 8. 
4 minutes. Salivation and borborygmi very marked 
24 minutes. Pulse, 49 ; temperature, 101 ; respiration, 3 ; saliva¬ 
tion very marked ; liquid evacuation. 
30 minutes. Evacuation and micturition. 
35 minutes. Salivation nearly ceased, but intestinal murmurs still 
audible. 
1 hour. All symptoms disappeared, but the animal showed some 
signs of weakness, shifting from one hind limb to another. No inflam¬ 
mation at point of injection. 
V. —CANINE. 
This was a one-year old greyhound weighing sixty pounds. 
Administered five milligrammes subcutaneously. 
Normal pulse, 85; temperature, 101.4; respiration, very much in¬ 
creased by applying a muzzle. There were no physiologic symptoms 
manifest, and the pulse remained normal. No inflammation at point of 
injection. 
VI. —CANINE. 
This was the same dog as in case number five, but injection 
was made one day later. 
Administered ten milligrammes subcutaneously. 
Normal pulse, 78; temperature, 100; respiration, 20; no muzzle be¬ 
ing applied. 
