PHYSIOLOGICAL EXPERIMENTS ON ARECOLINE HYDROBROMATE. 29 
line. The same physiologic action was repeated. In four days the 
animal was apparently sound. No local inflammation at point of n- 
jection. 
X.—OVINE. 
This was an aged sheep in emaciated condition. 
Administered five milligrammes subcutaneously. 
5 minutes. Salivation and intestinal murmurs. No very marked 
action was manifest. Sheep died before a second injection could be 
made. 
XI. —BOVINE. 
This was a two-year-old short-horn ox that had been sick 
for several weeks with chronic indigestion. 
Administered subcutaneously sixty milligrammes of areco- 
line hydrobromate in two doses three hours apart. 
5 minutes. Salivation and intestinal murmurs with the same symp¬ 
toms before manifest. This was followed by a line of treatment indi¬ 
cated by the case. Animal began to show some signs of improvement 
in ten days No local inflammation at point of injection. 
XII. —BOVINE. 
This was an aged black cow, weighing about eleven hundred 
pounds, with engorged rumen. 
Administered twenty-five milligrammes every two hours, 
until seventy-five milligrammes had been administered. 
Physiologic action was manifest at each injection. 
6 minutes. Salivation, much pain and intestinal murmurs. Cow 
made a complete recovery in twenty-four hours. No local inflammation 
at point of injection. 
XIII. —BOVINE. 
This was a six-year-old red cow sick with parturient apo¬ 
plexy. 
Arecoline hydrobromate was administered for its cathartic 
effect. 
Administered fifty milligrammes subcutaneously in two 
doses, one hour apart. 
Slight physiologic action manifest at each injection. 
Animal died. 
xiv.—EQUINE. 
This was a five-year-old brown mare that developed acute 
laminitis in all four feet; could hardly be made to move. 
Administered twenty-five milligrammes every hour until 
four doses had been given. 
The physiologic action was well marked at each dose^ with 
