652 
JAMES LAW. 
REMARKS. 
Without venturing to encroach on the pathological and bac¬ 
teriological results which will be dealt with by Dr. Moore, I 
may gather one or two of the lessons to be learned from this 
series of cases. 
First. We have a succession of cases of acute febrile disease 
in the horse due to a bacteridian infection, and manifested by 
an extreme and often fatal congestion of the lower respiratory 
mucous membrane and lungs (possibly also of the other organs 
in special cases). 
Second. In the casual (Monroe Co.) cases there was a pre¬ 
liminary stage in which the fever was scarcely marked, followed 
by a period of extreme hyperthermia (io6°), and there was great 
danger of a speedily fatal result. The illness in a mild form 
extended over about five days, whereas after the appearance of 
the hyperthermia the animal did not survive two or at most 
three days more. The Forest Home case was not seen until the 
hyperthermia had appeared, but she died within forty-eight 
hours thereafter. Our two inoculated cases did not die during 
the hyperthermia, but they showed this reaction in a very marked 
form, whether the virus was introduced into the blood, or the 
lung and pleura. In these the maximum temperature was 
probably reached by the fifth or sixth hour after injection, and 
it had returned to near the normal in twelve to twenty-four 
hours. In the thoracic inoculation 106.5° was reached in two 
hours, and as an afternoon temperature, 105° was maintained for 
two days. Then comparative defervescence ensued. The low 
morning and high eveuing temperature were 110 less remarkable. 
The small amount injected into the veins (ioc.c. and 14 c.c.) 
forbids the idea that hyperthermia resulted from the mere addi¬ 
tion of liquid to the circulating fluid, and this was corroborated 
by the high temperature which was more promptly secured by 
the inoculation into the chest. The enormous dose administered 
by the mouth produced a more moderate and tardy febrile reac¬ 
tion than the smaller doses inoculated. This might be partly 
explained on the ground that the system had already become 
