-8 — 
was streaked with red ; in other respects, nothing abnormal. 
The bile was thin and watery, even after standing twenty- 
four hours. The pancreas and spleen appeared natural; kid¬ 
neys normal; inner coat of bladder softened. Mem¬ 
branes of the brain congested and adherent ; the con¬ 
gestion may have been caused by a blow on the head 
previous to killing the animal. She was, however, only 
stunned by a light blow, and then immediately bled to death. 
The brain itself appeared pale, but the bleeding may have 
caused this. The membranes of the spinal cord were inflamed 
and adherent, the cord itself normal. 
“Evidently the disease was one of mucous and serous 
membranes, which would account for the nervous and debili¬ 
tated condition of the animal. The general diseased condi¬ 
tion of the alimentary canal, by interfering with digestion and 
proper nutrition, would account for stunted growth and weak¬ 
ness in traveling.” Here follows a quotation from New Rem¬ 
edies , August, 1882, page 226, where the physiological experi¬ 
ments of Dr. Isaac Ott, of Easton, are described. He goes 
on to state his own physiological experiments, and says they 
have given negative results: 
“So fully have I been impressed with the non-poisonous 
properties of the drug, that I have tried the effect of concen¬ 
trated solutions of it upon myself. Commencing at first cau¬ 
tiously with a dose of is minims every three hours, I have in¬ 
creased it from a tablespoonful to two tablespoonfuls (cor¬ 
responding to one ounce of the drug). This dose, although 
repeated at short intervals, produced not even the slightest 
effect upon the nerves, upon the pupil of the eye, and not 
much other than a stimulating effect upon the stomach and 
circulation. Similar experiments with the solution of the sup¬ 
posed crude alkaloid as prepared by Dr. Ott, were made. A 
tablespoonful of this solution gave not the least evidence of 
narcotism, although several times repeated. 
“I do not put forward these results as showing conclusively 
that this weed is not poisonous to horses and cattle. The sub¬ 
ject needs further study and close inspection, and is one the 
State of Kansas can well afford to spend money upon to se¬ 
cure the same. The State Board of Agriculture has done al¬ 
ready a very creditable work in this direction, and it is to be 
hoped they will continue unceasingly until the question is 
finally settled. I may state incidentally, that I am now mak¬ 
ing preparations to continue the work, in connection with Dr. 
Burleigh, during the summer of 1889, experiments upon her- 
biverous animals now being proposed. 
