— 13 — 
owed a greater craziness. The whole system was so run 
>wn that, in running and throwing himself, he bled profusely 
the nose. The unsteadiness and emaciation were the 
me as in the first case. The post mortem symptoms were 
e same, a description of one answering for the other. I 
id the brain from this case photographed and a cut made 
: it, which is appended.” 
Dr. Faville’s conclusion was that the loco contained some 
fisonous principle “that caused a hemorrhagic effusion into 
le base of the brain, causing symptoms of craziness and loss 
t muscular control.” During the fall of 1889, Dr. McEckran, 
len of the college, instituted the experiment of feeding the 
»co to an animal, the property of Hon. B. S. LaGrange, a 
lember of the State Board of Agriculture. I have not 
een able to obtain the record of the experiment, and can 
nly state the general plan and the conclusion of the exped¬ 
ient. The animal was placed in a stable and the loco ( As- 
mgalus Mollissimus and Oxytropis Lamberti) was cut up fine, 
nd mixed with other food so the animal would eat it. This 
ceding was continued about two months with no symptoms 
f the so-called loco disease. 
Enough has been given of the history of the loco and also 
f the symptoms by which the animals are affected. I have 
lade many inquiries of those that stated they had any exper- 
snce with the loco or locoed animals. 
!inford & Spencer, 
COAL DEALERS, , - oon 
Denver, Colo., September 27, 1890. 
). O'Brine, Professor Chemistry , Agricultural College , Fort Collins , Colo . .* 
Dear Sir—You will please excuse my apparent neglect in not complying with 
our request sooner, in giving you my experience with the loco .weed in New Mex- 
30 . The summer of ’81 was the most disastrous to stockmen that to my knowl- 
dge has ever occured in that Territory, and probably the cattle in Ute Creek Val- 
3 y suffered more than those on other streams. The loco weed was that bearing 
turple and white flowers ; the conditions were, dry weather and short grass. The 
lock ate freely of the weed, and at any time one could see horses and cattle in all 
itages of the disease, caused by eating thereof. The rough examination that we 
vere able to give the stock which died, showed the stomach and sometimes por- 
;ions of what is commonly called the manifold, to be lined and perforated by a 
small parasite. 
A certain druggist in Springer, whose name 1 cannot recall, hac a fair micro¬ 
scope. This we used in examining the plant. We found that almost every plant 
aad one or more leaves that were rolled, indicating that some worm or bug had 
been at work on it. These leaves, on being unrolled, contained a very small, white 
parasite. I cannot say that the two, that is the parasite in the stomach and the 
one in the leaf, had much resemblance to each other, in fact, rather the con¬ 
trary. But this, if our theory is true, might be due to the growth of the insect. 
It was the common opinion of those of us who were investigating this matter, that 
