96 
PROPHYLAXIS OF MALARIA. 
The method of administration as regards time will often depend 
upon military necessities, but it is best to give the quinine on retir¬ 
ing, or if it can be arranged the larger doses may be divided into 
equal morning and evening portions. The method may be easily 
remembered if stated as follows: Thirty grains of quinine daily 
until the plasmodia disappear, 15 grains daily for two weeks, 10 
grains daily for two weeks, and 6 grains daily for two months. 
If this method of treating these infections be faithfully carried 
out, it will be found that latent malaria will disappear and that none 
of the cases will become gamete carriers unless these forms of the 
plasmodia develop within a day or two of commencing treatment, 
when the treatment to be advised for destroying these forms should 
be adopted. 
The time to treat latent malarial infection is before the develop¬ 
ment of gametes because these forms are very much more resistant 
to quinine than are the forms concerned in the human life cycle and 
because the isolation and screening of the infected individual is 
necessary while treatment is being pursued if gametes are present. 
Any considerable number of gamete carriers in a military post is a 
reflection upon the treatment of malaria adopted by the responsible 
medical officer, and is proof positive of the improper treatment of 
acute and latent malarial infections. 
The treatment of u carriers ” in the prophylaxis of malaria .—One 
of the most important, and yet one of the most neglected, prophy¬ 
lactic measures against the spread of malarial infection is the dis¬ 
covery and treatment of “ carriers ” of the disease. It has already 
been stated that after a malarial infection has persisted for from 
8 to 10 or more days in man, forms of the plasmodia develop that 
are capable of further development in the mosquito, and that these 
eventually render this insect infective to man. These forms are 
called “ gametes " and they can easily be detected in the blood by 
microscopic examination. It is obvious that if these gamete carriers 
can be discovered and the gametes killed, these individuals will cease 
to be infectious to the mosquito; but despite this knowledge, this most 
important method of preventing malaria has been all but neglected, 
even in the military service. It has been shown that the gamete car¬ 
riers can be rendered harmless by proper treatment with quinine 
and that it is feasible to employ the drug in this way as a prophy¬ 
lactic against the disease. 
Discovery of gamete carriers. —The treatment of gamete carriers, 
.or carriers of the malarial infections, depends upon their discovery, 
and this depends entirely upon the examination of the blood of in¬ 
dividuals residing in malarial localities. The control of the treat¬ 
ment of acute and recurrent infections by frequent examination of 
