219 
EFFECT OF QUININE ON THE MALARIAL PARASITE IN 
(A) THE MOSQUITO AND (B) MAN 
A. Nearly all the infecting experiments were conducted on 
patients who were receiving the routine ward treatment of quinine, 
grains 10, ter. die , in solution, so that apparently quinine in these 
quantities has no destructive or inhibitive effect on the parasites in 
the mosquito because the zygotes go on to maturity and sporozoites 
appear in the salivary glands in from nine to eleven days. 
One experiment should be mentioned, however, because the 
patient received no quinine for several days before the mosquitos 
became infected and none during the experiment, so that the 
mosquitos never received any quinine. One Ce. albimana contained 
the rather large number of one hundred and sixty-eight zygotes upon 
dissection. It should be mentioned as well that from this patient 
two . 4 . pseudo pn net i penu is became infected. It may be that quinine 
has a slight inhibitory effect on the parasite in the mosquito s 
mid-gut. 
B. The following tables show the gradual but steady decrease 
in the number of gametes in the peripheral blood during the adminis¬ 
tration of quinine, grains io, ter. die , in solution, and one table shows 
the effect of withholding quinine. 
The differential leucocyte counts are tabulated as well, and in 
these the relative increase in mononuclear elements lymphocytes, 
intermediate, and large mononuclear cell — the latter being the chief 
circulating phagocytic cell in malaria. 
As indicative of blood regeneration and the secondary effect on 
the homopoietic organs, it is interesting to note the increase in the 
eosinophiles. 
LItART 5*499 _ __ 
Dec. 
3 ° 
Dec. 
3 ' 
Jan. 
z 
Jan. 
5 
Jan. 
6 
Jan. 
8 
Jan. 
13 
Jan. 
*5 
Jan. 
23 
l-'eb. 
1 
Polymorphonuclear . 
68 
6 5 
16 
I a 
75 
6 
81 
65 
6**5 
65 
5 1 
53 
66 
ii '5 
Large mononuclear . 
1 
5 
6 
> 3'5 
13 
11 
9'5 
18 
Lymphocyte . 
*T 
20 
'3 
11 
20 
16-5 
11 
>4 
Large lymphocyte— 
Intermediate . 
_ 
_ 
— 
8 
4 
' 4-5 
7-5 
I -»• c 
Eosinophilc 
7 
5 
2 
8 
7 
11 
l 4 
1 - 5 
Mast .... . 
f 
■ 
1 
t 
1 
1 
i -5 
O 
2 
1 
0-5 
Crescents . 
fjj 
12 
76 
46 
40 
* 5-5 
9 
5 
yJ 
- - 
xr f 
T 4 
— 
— 
— 
