220 
The table given above shows the rate of diminution in the number 
of gametes (crescents) by the administration of quinine, grains io, 
tci. die , in a Spaniard, 60 years of age, on Isthmus twenty months, 
whose blood contained numerous crescents but no young forms, and 
whose temperature was g;° F. continuously. It also shows the 
degree oi change in the proportion of eosinophiles, of increase in 
mast cells, very slight lymphocytosis and polymorphonuclear 
decrease. 
Compare this with the following: — Case 48,987 of malignant 
tertian malarial fever, from whom quinine was withheld for twenty- 
four days. Spaniard, on the Isthmus three months, temperature 
normal on admission. 
1908. 
Nov. 
11 
Nov. 
24 
Nov. 
2 7 
Nov. 
30 
Dec. 
4 
Polymorphonuclear 
86 
C 7 
Large mononuclear 
2 
53 
02 
4 2 
44 
Lymphocyte 
3 
22 
11 
16 
Large lymphocyte 
9 
0 
39 
'4 
46 
3 S 
Eosinophile 
2 
2 
2 
0 
0 
Mast 
3 
° 1 
1 
2 
Crescents ... 
I 
0 
o 
0 
0 
1 u 
27 
12 1 
1 
8 
20 
n this case the continuance of the gametes in the peripheral 
ood is sti iking. 1 lie polymorphonuclear decrease and the lympho- 
ytosis should be noted. I his patient received no quinine during the 
1 no etween November 11 and December 6. Young malignant 
, Cr lan f ° rmS Were a] ways present in his blood with gametes. His 
* tUrC UtlS | rre S u ^ ar » and irregularly quotidian in character, 
fi ' ^Panicud, on the Isthmus twenty months, temperature 
C . ’ 3 °° . Conta ined on admission many crescents but no young 
quinine, grains 10, ter. die , with Fowler’s solution, gtts. 5 - 
Chart No. 
Polymorphonuclear 
, r 6 e mononuclear 
Lymphocytes 
^ lnnp h« rt „- 
Eosinophile 
Crescents . 
53937 
Feb. 
5 
Feb. 
6 
Feb. 
8 
Feb. 
9 
Feb. 
11 
Feb. 
'4 
Feb. 
*5 
Feb. 
16 
Feb. 
'7 
69 
8 
iS 
4 « 
33 
4 1 
20 
4 2 
11 
40 
19 
5 2 
11 
33 
20 
40 
18 
39 
2 3 
3 
0 
*7 
8 
0 
2 3 
10 
34 
8 
28 
5 
22 '5 
io-5 
2 4 
6 
2 5 
>4 
2 3 
10 
2 
1 
6 
O 
1 
0-5 
0-3 
0 
2 
9 2 
87 
J* 
5 
48 
7 
20 
3-5 
3-5 
9 
4 
3 
3 
3 
2 
Feb. 
'9 
S *-5 
7'5 
23 
7 
0.5 
9'5 
V) 
