223 
In each of the above cases the rapid polymorphonuclear decrease 
and the equally rapid mononuclear increase should be noted. 
The effect of quinine administration, then, is to make the gametes 
gradually disappear from the peripheral blood by the destruction of 
the young forms, the gametes being phagocyted by splenic and hepatic 
endothelium. It is concluded that quinine, grains io, ter. die , in 
solution, will gradually reduce the sexual form of the parasite in man 
to a non-infective minimum in from a few days to a few weeks, 
depending on the severity of the infection. 
In simple tertian malarial fever, gametes disappear from the 
peripheral blood within two or three days under quinine treatment, 
and generally disappear even when quinine is withheld, if the patient 
is at rest. There are never as many gametes in the peripheral blood 
in simple tertian as in malignant tertian malaria. As a consequence, 
one never finds as many simple tertian zygotes as malignant tertian 
zygotes in infected mosquitos. 
