226 
England than in the tropics, and easier to treat it in the cool season 
in the tropics than in the very hot season—that is to say, I think that 
a given dose of quinine will produce least effect in the hot climates in 
which the parasites are most easily propagated. Moreover, if we 
make a careful study of statistics in India, we often observe a sudden 
rise in the malaria rate at the end of the cold season, long before 
any new brood of Anophclines has hatched out. True, this 
rise may be partly explained by the emergence of old 
Anophelines from hibernation; but it may also be due 
to relapses caused by the greater heat. There are also many observa¬ 
tions on record, especially in Italy, suggesting that season affects the 
plasmodia, especially the sexual forms, quite apart from the prolifera¬ 
tion of the carrying agents. Human trypanosomiasis occurs in persons 
in veiy hot climates, and may just possibly be retarded if such persons 
are removed to cold ones. In one case of complete cure known to me, 
marked improvement occurred when the patient was subjected to 
considerable cold, accompanied by healthy exercise and open air in 
Scotland. Dysentery seems to improve much more rapidly in cool 
climates than in hot ones. Possibly the effect may only be a slight 
one ; but it is well worth while to study whether there is any effect at 
, and if so how much because anything that concerns so important 
a matter as the treatment of disease is worth considering. Still greater 
ipioxement might be effected in many maladies, especially diseases 
e respiratory system, and of the skin, if cold is combined with a 
very dry and pure atmosphere, and, of course, with other forms of 
treatment. 
. ^ a V Car ’ l ^ cic ^° re » I asked Sir Edwin Durning-Lavvrence 
• r • 16 llot assist us to carry out researches on these points 
1 ■ ' erpo °; assented at once, and suggested that I should ask 
riend, Sir Alfred Haslam, the head of the great refrigerating works 
temnp 1 T l ° C °“ StrUCt a chambe r capable of being kept at the requisite 
made d 1^' hC re5U,t WaS that the Has,am Engineering Company 
made such a chamber at the University Laboratories of this School 
rU ptio ns T ,P |! ted ° n Septeaiber I0th > 1909, and after a few inter- 
William * aS CCn <ept cont,nu °usly running ever since. Major C. L 
Septemhe char ^ e of th e experiments from early in 
conducted by Dr. ^ pri1 ’ Wo, since when the work has been 
■ J- ■ homsOn. At the time when Dr. J. G. 
