230 
Of the remainder, three controls failed to develop tumours, and 
one each in the control and cold chambers died within a few days of 
inoculation. 
Six mice were also put into the cold chamber uninoculated as 
controls, and of them two are still alive (21 Feb.), well and vigorous, 
after 120 days, showing - that cold per sc had no bad effect on them; 
whilst two were eaten by their comrades after respectively 24 and 42 
days residence in the cold chamber, and two died of natural causes in 
56 and 62 days. 
Some mice were also infected with Spirochaetn duttoni, but no 
appreciable influence on the course of this disease could be observed in 
them. 
Five guinea-pigs with tetanus were placed under observation, a 
case of a boy cured of that disease whilst being treated in a refrige¬ 
rator having been reported by Crane (‘ St. Louis Medical Review//th 
July, 1906). Of the tetanus guinea-pigs, one injected with ^ c.c. 
of a culture and placed in the cold chamber, died in 9^ days, but it is 
veiy doubtful if it died of tetanus : two injected with ,5^5 and 
1 uno c.c. respectively and kept as controls never showed any 
symptoms; whilst two injected with c.c. and placed one in the 
cold chamber and one as control died with similar symptoms in a 
similar time—something over 30 hours. 
An Englishman suffering from sleeping sickness of some three 
months duration, and contracted in N. Rhodesia, was submitted to 
a course of treatment in the chamber from January 5 onwards to the 
end of that month. Ordinarily he came from the hospital in which he 
y cab about 10 a.m., and rested in the chamber, well wrapped 
p, ti about 3.30 p.m. In all he had a course (interrupted for some 
cays) o twelve days, or some 53 hours in all, of cold air. The tern* 
perat ure wag gradually decreased till 24 0 F. was reached. He himself 
sai ie elt much better for the treatment, which acted on him as a 
,• . . U * 111 tbe s ^ lort period he was under observation no visible 
on w as apparent in the number of trypanosomes in the blood. 
W n S ff . e . ttlng atox y 1 simultaneously at his hospital. Several times 
rest t • ac k_j~ a cl,stance of fully il m jle S —after his cold chamber 
and h l \, SmC r 1<ebruar > / 1 he has not been able to leave the Hospital, 
; cl has therefore been unable to utilise the action of cold in altering 
and thereby the culture media his bod >' of T ■ 
