2 JO 
4. The cases studied by us numbered thirty-three. All had 
been infected in West Africa or America, so that none was of less 
than some weeks’ duration when admitted into hospital in Liverpool. 
All were males of from eighteen to sixty years of age. They were 
mostly shipmen or traders, and two were negroes. The parasites 
of all were counted almost every day, and sometimes several times 
a day; and the temperatures were taken every four hours, or more 
often. One case showed Plasmodium malariae, together with 
crescents (sexual forms of P. falciparum). Eight showed P. vivax 
only, and twenty-four P. falciparum only, two of the latter 
containing only sexual forms. Quinine was often withheld for 
some days while other methods of treatment were used. The 
cases were studied for 600 days altogether. There were no 
deaths. 
All the cases are tabulated at the end of the paper for 
verification of details, and charts of cases 17 and 20 are given. At 
this preliminary stage of the enquiry we have undertaken to study 
only the gross daily correlations between the numbers of parasites 
and other phenomena, leaving more minute hourly and four-hourly 
analysis to future work. Hence if a number of counts or other 
observations have been made on one day we have recorded only the 
averages in the tables. For temperatures, however, it has been 
thought best to record maxima instead of averages, and, as the 
tables should be as economical as possible, we have used the 
laematothermic scale suggested by one of us (R.R.), in which the 
ten degrees between 95 0 and io 5 °F., or between 35 0 and 45 ° C., are 
im ed into 100 parts. Except Case 6, specially studied by Dr. 
ant ram, we ha\e not distinguished in the tables the various forms, 
sets or stages of P. vivax , this being reserved for future study. 
* treatment> leucocytes, haemoglobin and urobilin are 
1 ferentiated too minutely. Case 25 was counted by Dr. Korke. 
5 - The correlation between the parasites and the fever. It is 
now n that fever is caused only by the asexual forms of the 
, aS .j teS ’ kut though these are generally thought to be more 
un ant during pyrexial periods, no extensive numerical 
t-hai- S >n P °* nt a PP e ar to have been made, with the result 
elcLTT SCGPtiCS StiU profess doubts on the subject. Our cases, 
except four without fever (Cases r, 15, r6 , 27), would seem to 
