28 o 
5 to io grain doses on five occasions during twelve days, and yet a 
smart relapse occurred during and after the last dose. In the same 
case just before the same relapse X-rays had been applied over the 
spleen and abdomen for twenty minutes. The asexual parasite rise 
had commenced before the application. In Case 24, faradic and 
galvanic currents were applied over the spleen, each for ten minutes, 
but crescent counts made immediately before and two hours after 
the application remained unaltered 
13. Haemoglobin. This was estimated in most of the later 
cases. I'he percentage always fell during fever and began to rise 
rapidly shortly afterwards, proving the destructive effect of the 
parasites and the rapid recuperation of the patients. The greatest 
fall was 25 per cent, after four days’ fever (Case 20); but more 
detailed work is required to trace correspondence with the number 
of parasites. 1 he lowest percentage found was 53 per cent. All the 
patients were anaemic at first, but the haemoglobin rose rapidly with 
improvement of health, and very rapidly in the more vigorous subjects. 
We decided not to attempt counts of red corpuscles, as these have 
been made so frequently already. The elimination of the haemoglobin 
and the findings in a case of blackwater fever will be dealt with in 
the two following papers by Dr. Simpson and in one by ourselves. 
14. Summary. (1) There would seem to be a very decided 
correlation between the number of asexual Plasmodia found in the 
peripheral blood and the fever. 
(2) As a rule, no fever exists unless the asexual forms exceed 
some hundreds per c.mm. 
( 3 ) The asexual forms do not always disappear between relapses 
(as often thought) but tend to persist in small numbers per c.mm.. 
an often increase again for some days before the actual febrile 
relapse occurs. 
(4) These observations give a coherent theory of the malarial 
n\ asion, according to which the infection is kept alive indefinitely 
y tie ordinary sporulation of the asexual forms, and not by 
P t enogenesis or by resistant forms; and fever recurs only wh en 
the parasites are numerous enough to produce it. 
