Liverpool, on the 2nd June, 1910, owing to the continuance of sue! 
attacks. His weight was 114 pounds (52 kilograms); he looker! 
pale, thin and anaemic ; his liver was enlarged half an inch below 
the costal margin, but his spleen, though enlarged, was scarce!; 
palpable. 
As shown on the chart, on the day of admission 2,600 asexual 
forms of Plasmodium falciparum were found per c.mm. of his blood 
accompanied by the usual fever. On the following five days the 
same parasites numbered 80, 1,360, 880, 20, and 12 per cm, 
accompanied by fever on the 2nd, 3rd, and 4th days after admission 
Quinine hydrochloride (10 grains) was given on the 4th day and 
30 grains daily until the 10th day inclusive. No parasites were 
found on the 7th and 8th days, and no fever occurred on the 5th. 
<>th, 7th and 8th days. On the 71I1 and 8th days he was allowed 
out of hospital for a few hours in the afternoon, and on the latter 
da y g°t heated with exercise, and ate ices. 
On the 9th clay/ he was attacked with high fever with rigors. On 
the 10th day/ haemoglobinuria commenced and the quinine was 
stopped. Lire attack was very serious. The haemoglobinuria 
cleared up on the evening of the 11th day, but the fever continued 
to a diminishing degree until the 1 Sth day/, though the temperature 
occasionally rose slightly above normal until the 37th day. fl ,ere 
was then a break for tour days, on the last of which he was again 
allowed out of hospital. On the 42nd day another severe pyrexial 
period commenced, lasting until the 54th day, but not accompanied 
by any haemoglobinuria. The patient now improved greatly and 
was discharged on the 63rd day/; but returned again to hospital on 
the 70th day with fever (which, however, was not examined by us, 
but no blackwater. I he parasites were carefully searched for (6 
TT 1.), both m thick and thin films, on forty day’s up to the 49th da; 
°f dle c ^ sease ’ a fter which, unfortunately, the examinations could n 1 
be continued. On not a single occasion since the 6th day of the 
disease could a single Plasmodium be found, though during the 9 th ' 
IOth and IIth da y s . that is, during the blackwater period, the blood 
was examined by both methods four times daily. No crescents ' vere 
ever seen. 
It should be noted that the haemoglobin of the blood, estimated 
^ ,v ky Sahli’s haemoglobinometer, began to fall on the M- 
