317 
The figures are very high indeed, and equal, in some instances, 
any figure that I have found recorded by other observers; their 
special interest is that they show the destruction and elimination 
of a very large proportion of the haemoglobin of the circulating 
blood; I propose, however, to leave the question of urinary urobilin 
at this stage and proceed to consider the elimination by the bowel. 
As will be seen later urinary urobilin would appear to be simply a 
leakage—rarely an important one—from the other channel, and it 
has only been alluded to in consideration of the great attention 
that has been paid to it in the past, and since in the present instance, 
it was largely the promise held out by the results obtained in Cases 
n and 13 in the early days of January, that led to my persisting 
in further work along these lines. 
Note.—Since writing this paper I have become acquainted with 
Dejonge’s* results, he found urobilin in malarial urines in amounts 
of from 0-05 to o’10 gram per diem, and this frequently rose as 
high as 1 gram and occasionally even to 4 grams. The difference 
may be accounted for by the fact that his cases, unlike mine, were 
frequently treated with quinine, which he found to increase the 
urobilin output. He found however lower outputs in malignant 
tertian malaria than in benign tertian, a result very different from 
mine. 
IV. FAECAL UROBILIN 
{a) It would be out of place in the present paper to discuss at 
an )' length the methods of extraction and estimation of urobilin 
from the faeces, but perhaps I may be pardoned for alluding to a 
few points of interest. 
After considerable controversy it has been shown that urobilin 
°f identical quantitative composition can, by various processes, be 
Prepared from faecal and urinary sources. It would appear, 
however, that much of the urobilin in the faeces is present in 
modified forms (possibly in part in union with metallic salts) since 
' l has a fluorescence and occasionally a spectroscopical appearance 
somewhat different from that of urinary urobilin; on one or two 
occasions I was very much puzzled by obtaining a solution much 
Geneesk. Tijdschr. v. Nedcrl.-Indie, Dccl XLIV, p. 435' , 9 ° 4 - 
