r 
335 
cases which had quinine and picric acid also, in the cases in which 
more or less complete observations were possible. 
This table clearly shows that cases which received the picric acid 
treatment lost the crescents earlier than those which had no picric 
acid. The only case of picric acid treatment where the crescents 
continued to appear in the blood for sixty-two days was one of the 
most severe cases of malaria that 1 have seen. The patient, who was 
a deaf mute, was quite moribund for days together; while the 
analogous case without picric acid treatment from the start showed 
very few crescents— in fact, the ordinary smears did not show any. 
The cases which lost their crescents within ten days must be 
regarded as cases that had probably come at the end of the crescent 
infection stage and thus lost them early. 
Out of four cases in which crescents disappeared between ten and 
twenty days, three absconded, and hence they are put down as 
incomplete cases, while it is quite possible that the fourth case had 
come at the end of the crescentic infection ; in fact, he was admitted 
for croupous pneumonia, and crescents were only found on 
examination of the blood as a routine method. It is not at all likely 
that the pneurnococcic infection could produce destruction of the 
crescents, because the case in the simple quinine group that had 
crescents for sixty-two days was also suffering from the same disease 
at the time of admission in the hospital. In the quinine group which 
lost the crescents between twenty and thirty days, one case is 
marked incomplete for the same reason, viz., that he absconded 
with the crescents in the blood. 
It must be borne in mind that all the cases that received the 
picric acid treatment were cases of specially severe infection, so that 
the fact that fourteen out of seventeen lost their crescents between 
ten and thirty days compares very favourably with the four out of 
seventeen of the quinine group which lost their crescents during the 
same period. 
Again, on referring to Table ' B,’ one finds that the death-rate 
was higher in the quinine treated cases, whether those had the spleen 
enlarged or not, as compared with cases which had the picric acid 
treatment also. 
Of course the number of cases is not large, but one must bear in 
m ind that crescent rases as a rule are not found in large numbers, 
