3&5 
A NOTE ON THE PATHOLOGY OF 
LESIONS OF THE CORNEA AND SKIN 
IN ANIMALS EXPERIMENTALLY IN¬ 
FECTED WITH T. RHODESIENSE 
BY 
WARRINGTON YORKE, M.D. 
[From the Runcorn Research Laboratories of the Liverpool School 
of Tropical Medicine). 
Received for publication 2 November, 1910) 
As mentioned in a previous paper three goats and a horse 
infected with T. rhodesiense all developed an interstitial keratitis 
of a remarkably transient character. 
Goat 1. On the sixth day after inoculation the temperature rose 
to 107° F. and parasites appeared in the peripheral blood, one being 
found to a field (Zeiss objective DD, eye-piece 4). During the 
next five days parasites were present in the blood in small numbers, 
one to from twenty to fifty fields. Subsequently the temperature 
fell to 103° F., and except on the thirty-first day, when one 
trypanosome was seen in fifty fields, parasites were not again found 
in the blood until the day of death, which occurred on the fifty-fifth 
day after inoculation, when one trypanosome was present m fifty 
fields. 
On the fifteenth day a distinct swelling of the skin and 
subcutaneous tissue was visible below the eyes and o\er the nasal 
bones. This condition became gradually more marked and 
persisted until the animal’s death. 
On the seventeenth day it was noticed that the lower portion of 
the left cornea was slightly milky in appearance. This cloudiness 
rapidly became more dense, until on the nineteenth day the woe 
of the lower two-thirds of the left cornea was densely opaque. 
• Yorke. ‘On the Pathogenicity of a Trypanosome (T. rbodestense) Join 
Sickness contracted in Rhodesia.' Ann. Trop. Med. and Parasitol.. VoL IV, p. 
a case of Sleeping 
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