3&7 
In none of the goats was any other pathological condition of the 
eye observed. The pupils dilated normally with atropine. There 
was no conjunctivitis nor injection of the sclerotic. 
HORSE i. Parasites were first found in the blood on the seventh 
day. Subsequently they were present regularly in small numbers 
until the animal’s death on the thirty-eighth day. 
Slight haziness of the left cornea was first apparent on the 
thirty-fifth day. The condition gradually increased in severity, 
until at the time of death the whole cornea was cloudy. 
The right cornea was unaffected. 1 he sclerotic of the left eye 
was slightly injected. 
For the purpose of studying the histological appearances the 
eyes were removed at the time of death and small portions of the 
cornea fixed in various fluids, viz., formalin io per cent., 
Flemming’s solution and mercuric chloride alcohol. I he tissues were 
embedded in paraffin and the sections stained with Heidenhain’s 
iron alum hacmatoxylin, Breinl’s safranine methylene-blue orange 
tannin, Giemsa and van Gieson. The best results, so far as the 
staining of the parasites was concerned, were obtained by staining 
the tissue which had been fixed in Flemming’s solution by either 
the iron alum haematoxylin or the safranine methylene-blue orange 
tannin method. In well-fixed sections stained by these methods 
the trypanosomes stained exceedingly well, and the different 
portions of the parasites were easily distinguished. On the other 
hand, in those which had been fixed with formalin, the parasites did 
not stain, or at the best were very indistinct. 
For purposes of description the eight corneae examined may be 
grouped into four classes. 
I. Those which were densely opaque at the time of death, viz., 
left cornea of Goat l and the right of Goat 3. In these the moibid 
changes were very marked. The pathological conditions in the two 
were somewhat different. In the left cornea of Goat 1 the lesions 
were entirely confined to the substantia propria, the anterior and 
posterior epithelial layers being unaffected. Scattered throughout 
the substantia propria, which was almost twice as thick as that of a 
normal eye, were small oedematous patches. These were situate 
for the most part in the anterior third of the substantia propria. In 
the distended interlamellar spaces were a few leucocytes v both 
