anterior and posterior epithelial layers were normal. 1 he 
substantia propria was slightly thicker than normal and oedematous 
in places. Near the corneo-sclerotic junction there was considerable 
infiltration of polymorpho- and mono-nuclear leucocytes and some 
new vascular formation, but elsewhere only a few leucocytes were 
found. No parasites were seen. 
IV. The left cornea of Goat 3 and the right of the horse, which 
had remained unaffected throughout the disease. In these nothing 
abnormal was observed microscopically. 
A comparable condition of affairs was found to exist in the 
lesions of the skin of an infected rabbit. 
Small pieces of skin were removed from the following different 
areas:—(#) Normal skin of back; (£) area recently affected in which 
the hair was being shed and the skin oedematous; ( c ) bald markedly 
oedematous area; ( d ) region which had been bald for some weeks 
and showed some signs of recovery. 1 he thickening of the skin 
had largely disappeared and there was a slight re-growth of hair. 
The methods of fixing and staining were those employed for the 
cornea. 
The histological appearances presented by sections of skin from 
these different areas may be classified as follows : — 
( a ) No pathological changes and no parasites were found. 
( b) Large numbers of trypanosomes were found lying in the 
oedematous interstitial spaces. There was also considerable 
cellular infiltration. 
(c) In this region the skin was considerably thickened and 
markedly oedematous. Enormous numbers of trypanosomes were 
present. There was great cellular infiltration involving the hair 
follicles and glands. Many of the hair follicles had completely 
disappeared. 
(d) Here no parasites were found. The skin was not distended 
with fluid and the cellular infiltration was only slight. 
Judging from the appearance presented by this series of sections 
of the cornea and skin the course of events would seem to be 
somewhat as follows: — 
In early lesions trypanosomes are present in the tissues, and as 
a result there is an oedematous condition of the part, and a more 
ur less marked degree of leucocytic infiltration. 
