Later as the number of parasites increases the morbid condition 
becomes more accentuated. Large numbers of leucocytes are poured 
into the tissue and new vessels develop. After a time the parasites 
disappear and with their disappearance there is a tendency on the 
part of the tissue to recovery. 
The rapidity with which these processes occurred in the cornea 
is very remarkable. One can hardly suppose that the changes in the 
right cornea of Goat i and the left of Goat 2, which from being 
densely opaque were after the interval of a few days apparently 
normal, had progressed so far as the formation of new vessels; yet, 
on account of the extreme opacity, there must have been very 
considerable cellular infiltration, although this might in part be 
explained by the presence of enormous numbers of parasites such as 
were seen in the left cornea of Goat 1, which was densely opaque at 
the time of death. 
I he fact that trypanosomes can multiply so readily in the tissue 
spaces and at the same time be either entirely absent from the blood, 
or present in very small numbers only, is one of considerable 
interest, although the explanation is not very obvious. Perhaps 
the tissue juices form a more favourable nidus for the growth of 
the parasites, or possibly in these situations they escape to some 
extent the action of certain anti-bodies which have been shown to 
exist in the blood. Whatever the cause may be, the observation 
illustrates in what manner it is possible for an animal to be heavily 
infected and at the same time present no parasites in the peripheral 
circulation. 
J he drawings were clone by Miss A. M. Brookfield. 
