He was admitted into the Royal Southern Hospital on 
December 4. Daily estimation of the number of trypanosomes per 
cubic millimetre of his blood was commenced on February 16, and 
continued till his death on June 29. a period of 134 days. During 
that period we never failed to lind trypanosomes. The history 
of the case from February 16 is recorded graphically on the chart. 
The patient had glandular swellings and ill-defined 
erythematous rashes on his legs at various intervals. On April 20 
he had a severe attack of vomiting which continued for four days; 
in consequence he lost 10 lbs. in weight and was never again so 
well. He remained in bed onwards till his death. He became 
progressively more drowsy, with intervals of more or less 
comparative brightness. His memory and mental powers failed 
steadily. On May 7 he developed a marked neuritis due to the 
atoxyl, and every dose seemed to aggravate the neuro-retinitis 
produced by the previous administration of this drug. His eyes 
were examined weekly by Dr. Hamilton, oculist to the hospital. 
On May 10 both legs became markedly oedematous and 
remained so till his death. On May 13 he became much worse and 
developed paralysis of his sphincters. He seemed about to die. 
but on May 20 a sudden remarkable improvement took place. Soon, 
however, he again commenced to grow steadily worse. 
On June 25 he developed pleurisy and pneumonia. He died on 
June 29. 
Post mortem. — Performed twenty-two hours after death: — 
Brain. Membranes thickened and white. Vessels congested. 
( erebrospinal fluid increased. 
£ eft lung. — Broncho-pneumonia. 
l-eft -pleural cavity. —Contained one pint of yellow pussy fluid. 
Spleen. Soft and much enlarged ; weight, 33 ozs. 
Liver. —Enlarged; weight, 6 lbs. 
Blood. — No trypanosomes could be found. Leucocytes, 
'7.000 per cubic millimetre. Polymorph excess. 
Smears of bone marrow, spleen, kidney, mesenteric glands, and 
1 eiebrospinal fluid, all showed large numbers of small and large 
mononuclear cells, but no trypanosomes could be detected. 
