477 
the blepharoplast (kinetonucleus,. At t his stage the parasite forms 
at its drawn-out anterior end an undulating membrane along the 
edge of which the flagellum lies, and the organism somewhat 
resembles a Crithidia. This transitory stage may be termed the 
crithidial stage. The organism grows and the blepharoplast passes 
posterior to the nucleus, and the trypaniform stage is assumed. 
The evidence of stained preparations (figs. 32 to 40) fully 
supports this mode of formation of flagellate trypanosomes from 
non-flagellate latent bodies. file latent bodies, which are the 
post-flagellate stages ot one generation of trypanosomes, become 
the pre-flagellate stages of the succeeding generation of 
trypanosomes. Such prc-flagcllatc, ( rithidia-like parasites in 
various stages ol metamorphosis may be seen in the peripheral blood 
of the host (figs. 32, 34 to 42), when the parasites are increasing in 
numbers therein. 
A basal granule (blepharoplast of Minchin) is seen at the base 
of the flagellum of some stained flagellating parasites (fig. 3 /)- 
It may be added that in dealing with an isolated case of an 
intermediate stage of a parasite between the flagellate and the 
rounded body, it is sometimes difficult to determine whether the 
given stage is pre-flagellate or post-flagellate, that is, whethei the 
given parasite is proceeding in development towards the flagellate 
stage or away from it towards the rounded bod)’. 
the significance of the non-flagellate or latent 
FORMS OF TRYPANOSOMES. INOCULATION WITH 
LATENT BODIES PRODUCES TRYPANOSOMIASIS 
R. Ross and 13 . Thomson (1910) report periodic variations m 
the numbers of the trypanosomes found in the blood of a patient, 
W. A., suffering from Rhodesian Sleeping Sickness. Fantham anc 
J- G. Thomson (1910) report similar periodic \ ariation in tie 
number of the parasites in the peripheral blood of sub inocu ate 
animals (rats, guinea-pigs, and rabbits). During the P® rl ° s ° 
decrease of the parasites in the peripheral blood, I n ia 
latent (non-flagellate bodies arc present in relativelylar to e nu 
in the internal organs of the host. 1 he latent bodies are orme 
at or near the period of maximum increase of the trypanosomes 
the peripheral blood. The latent bodies are especially numerous 
