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SUMMARY AND CONCLUSIONS 
1. Non-flagellate stages of trypanosomes, such as T. gambiense 
(Dutton) and T. rhodesiense (Stephens and Fantham), occur. 
2. These non-fiagellate stages (‘ latent bodies ’ of Moore and 
Breinl) are especially found in the lungs, spleen and bone marrow, 
during periods of decrease of trypanosomes in the peripheral blood 
of the host. 
3. They are in process of formation at or near the time when 
the trypanosomes are most numerous in the peripheral blood. The 
formation of latent bodies takes place especially in the lungs, and 
they collect in the spleen and bone marrow of the host. 
4. In the formation of non-flagellate stages, some of the 
cytoplasm and the flagellum of the trypanosome are disintegrated. 
The non-flagellate body contains the nucleus and blepharoplast 
(kinetonucleus) of the trypanosome. 
5- Non-flagellate (latent bodies can be seen to grow and 
flagellate, turning into trypanosomes, when placed in fresh, warm, 
uninfected blood. 
6. Latent bodies of T. rhodesiense , inoculated into a rat, 
flagellate and produce trypanosomiasis. 
The non-flagellate (latent) bodies of trypanosomes (T. 
gambiense and T. rhodesiense) are the post-flagellate stages of one 
generation of trypanosomes and the pre-flagellate stages of the 
succeeding generation of trypanosomes. 
8. There is a life-cycle of trypanosomes (T . gambiense and 
T. rhodesiense ) in Vertebrate hosts, comparable with those of 
Crilhidia and Herpetomonas in the alimentary tracts of various 
Invertebrates. The latent (relatively resistant) stages o 
trypanosomes occurring in Vertebrates are separate from, and 1 
addition to, stages of the parasite which may occur in t e 
Invertebrate carrier (for example, Glossina). 
9 - In the treatment of trypanosomiasis by drugs, careful n 
mu st be taken of the occurrence of rounded non-flagellate or 
forms of the parasite. A drug needs to be found which W1 ^ 
prevent the formation of rounded (latent'' stages, or disi 
those latent bodies already formed. 
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