499 
Rat 38—continued. 
Day . 
43 
44 
45 
46 
47 
48 
49 
Number of Trypanosome* per 
c.mm. ... 
317,856 
218,880 
231,840 
211,520 
112,640 
190,520 
664,608 
Atoxyl 5 per cent, solution 
— 
— 
— 
— 
— 
— 
Leucocytes . 
21,924 
— 
31,020 
9,280 
26,048 
19,404 
33 i 120 
Day . 
5 o 
5 « 
I 
— 
— 
Number of Trypanosomes per 
c.mm. 
816,960 
1,500,000 ’ — 
— 
— 
— 
— 
Atoxyl 5 per cent, solution ... 
— 
— 
— 
— 
— 
Leucocytes . 
63,480 
1 
— 
— 
; 
The above animal, Rat 38, lived fifty-one days. The control 
of this animal weighing 238 grams lived eighteen days, and the 
day before death had 350.000 trypanosomes per c.mm. Rat 3b 
received two doses of a 5 per cent, solution of atoxyl (o'5 c.c.. 
subcutaneously, and it will be noted that this dose calculated to the 
body weight of a man of 70 kilograms would be 130 grains 
approximately. It is of interest to note that the leucocytes rose m 
Rat 38 on the thirteenth day to 63,000 per c.mm. 
Two other rats infected with the same strain received doses of 
o'5 c.c. of a 5 per cent, solution of atoxyl. 
Rat 40, white, weight = 129 grams. 
Rat 41, white, weight =113 g rams - 
Rat 40 had 4,800 trypanosomes in the cubic millimetre befoic 
injection, and next day we found S9 per c.mm., i.e., twent) 
hours after injection of atoxyl, and in forty-eight hours there were 
no trypanosomes in the peripheral circulation. . . f 
Rat 41 had 7,056 trypanosomes per c.mm. before mjec ion o 
atoxyl and next day two, presumably dead trypanosomes, we e 
found in a thick film. Tins rat, however, succumbed to the toxic 
action of the drug the following day. 
Atoxyl, therefore, in large doses is a trypanoci e. ; rs 
so-called poisonous doses causes adverse conditions in c , 
