we get fattv degeneration, especially of the cells of the liver and the 
epithelial cells of the stomach and intestines, and to a lesser extent 
in the kidneys and other organs in the body. If, therefore, we give 
atoxyl in a poisonous dose to an animal we kill not only the 
trypanosome cells, but also the body cells. 
Unfortunately, in this strain of trypanosomes, even after the 
large dose of atoxyl given, the parasites appeared again in Rat 3 
after an absence from the peripheral blood of four days. 1S “ 
only to be explained by the resistant forms of Moore and Brein 
(Ann. Trop. Med., I, page 45 7 (W)) forniing ,n ^ f L 
bone marrow, and these again flagellate out un er avour 
circumstances. . • . 
Thomas and Breinl pointed out that to obtain a cure we 1 
approach as near as possible to the lethal dose. •. 
A small dose of atoxyl repeated did not act as a trypanoerfe, 
but we would suggest prolonged the life of the amma y 
"Tlarge dose of atoxyl, on the other hand, is 
trypanocide, and clears the peripheral circulation o 
but in this strain, T. rhodesiense, which is a p action of 
one, the trypanosomes were evidently able to resis 
the atoxyl by encysting themselves in the spleen and bone ma 
(Moore and Breinl")- 
Our conclusions are briefly these . ^ 
CO Small doses of atoxyl, i.e., therapeutic pro bably by 
viz., T. rhodesiense, prolong the life of the 
raising the body resistance. . trvDan osomes actually 
(2) Small doses of atoxyl in this stram of trypan 
stimulate division of the parasites. probably do 
( 3 ) Large doses of atoxyl kill the P* r bod j es (Moore and 
not cure the animal owing to atoxy ie ^ marro w. 
Breinl) being formed in the spleen and on forms oi 
(4) As has been noted by other °^ r ' e ^ ^ bg expected . 
this disease, the initial dose must be ar b but would a PP ear 
( 5 ) Atoxyl is noi a specrfic in T. the trypanosomes 
to be almost as toxic to the bo y 
themselves. __-— 
' Ann. Prop. Med. and Parasit., Vol. L P- 457 C 907 
