525 
The conclusions to be drawn from the above experiments are 
therefore in favour of treatment in the cold. The resistance of the 
animal is evidently raised, for the incubation period is delayed, 
and the animal lives longer in the cold. In favour of the cold 
also, we have the evidence of the patient, W.A., who said he felt 
better when in the cold chamber. What the physiological action of 
cold is we are not prepared in our present state of knowledge to 
state, but we certainly think that a person warmly clad is 
beneficially acted upon by a cold, dry atmosphere, and we would 
suggest that patients suffering from sleeping sickness would be 
greatly benefited by a sojourn, say, in Canada or Switzerland. 1 he 
cold seems to be a valuable therapeutic agent in treatment. 
We must acknowledge the fact that much more must be done 
in this investigation before definite conclusions are drawn, but 
the results have been so encouraging that we think they ought to 
be made known at once. 
IV. X-RAYS 
A young piebald rat, weighing 77 grams was inoculated with 
the Rhodesian strain of trypanosomes. 
Here we have to thank Dr. Morgan, in charge of the Electrical 
Department at the Royal Southern Hospital, who kindly advised 
us in the administration of the rays. I he exposures to the rays 
were given by Miss Wells, an experienced worker, under the 
supervision of Dr. Morgan. The rat lived fifteen days, and we can 
therefore say that this animal’s life was prolonged, when compared 
with the average life of twenty-two untreated rats, which was 
1 1'3 days. 
In spite of five exposures, each of twenty minutes duration, 
during which period the whole body of the rat was exposed to the 
direct action of the rays, the trypanosomes remained lively and 
increased steadily in number in the peripheral circulation. 
The rays were not, therefore, trypanocidal in the exposures 
given by us, but, curiously enough, the life of the animal 
prolonged. 
