5 5 ° 
instead of forming rouleaux, tended to clump together into masses 
and to lose their outlines. 
More recently Christy* * * § (1904). Dutton and 1 'oddt (1905), 
Martin, Lebceuf and Roubaud* (1906-8), and others have described 
a similar condition in fresh preparations of the blood of patients 
suffering from sleeping sickness. 
Dutton and Todd,§ referring to this condition of the blood, 
wrote: ‘ Only once have we had the opportunity of observing a 
* patient (European' from whose blood trypanosomes, once present, 
* have finally disappeared.’ In this instance auto-agglutination ot 
the red cells disappeared with the parasites. 
Later, it has been noted by many investigators! that the 
phenomenon gradually disappears in animals after the successful 
drug treatment of the disease. 
In spite of the fact that auto-agglutination of the red cells in 
trypanosomal infections has attracted so much attention, very little 
work appears to have been done with a view to determining the 
nature of the changes in the blood which lead to its manitestation. 
Most of the workers have contented themselves with simply 
recording the presence of the phenomenon. So far as I have been 
able to ascertain from a search of the literature, only two authors 
mention any details regarding the mechanism of its production. 
Kanthack, Durham and Blandford stated that the serum of the 
blood of animals exhibiting auto-agglutination, when added to 
normal blood of the same species of animal, caused the red 
corpuscles to clump together. On the other hand, at a recent 
meeting of the Society of Tropical Medicine and Hygiene, in the 
* 1 Sleeping Sickness,’ British Medical Journal, 1904, p. 1456. 
t ‘ Gland Puncture in Trypanosomiasis.’ Memoir of the Liverpool School of Tropical Medicine. 
1905, No. 16. p. 99. 
. Rapport de la Mission d Etudes tie la Maladie du Sommeil au Congo Fran^ais, 1906-8, p. *8i- 
§ Lor. eit. 
II Thomas and Breinl, ‘ Pathology and Treatment of Trypanosomiasis,’ Memoir of the Liverpool 
School of Tropical Medicine, 1905, No. 16. 
Mcsnil, Nicolle. and Aubcrt, ‘ Rcchcrchcs sur le Traitement des Infections Experimental^ 
a T. gamhtense,' Annales de l’lnstitut Pasteur, 1907, Vol. XXI, p. 1. 
and Thiroux. ‘Sur le Traitement des Trypanosomiases,' Bulletin Soc. Path. Exot.. 
Martin and Darre, ‘ Surges Symptomes Ncrveux du D£but de la Maladie du Sommeil.' Bulletin 
Soc. Path. Exot., 1908, p. 15. 
