202 POISONS : TIIEIR EFFECTS AND DETECTION. [§ 253 . 
In a single experiment on a small dog, the weight of which was 
5525 grms., the dog died in six hours after a dose of 600 mgrms. 
It is therefore probable that a dose of 100 mgrms. per kilo, would 
kill most warm-blooded animals. 
A transient exposure to dinitro-benzol vapours in man causes serious 
symptoms ; for instance, in one of Huber’s cases, a student of chemistry 
had been engaged for one hour and a half only in preparing dinitro- 
benzol, and soon afterwards his comrades remarked that his face was of 
a deep blue colour. On admission to hospital, on the evening of the 
same day, he complained of slight headache and sleeplessness ; both 
cheeks, the lips, the muscles of the ear, the mucous membrane of the lips 
O 
180 
Diagram of Visual Field. 
and cheeks, and even the tongue, were all of a more or less intense 
blue-grey colour. The pulse was dicrotic, 124 ; T. 37*2°. The next 
morning the pulse was slower, and by the third day the patient had 
recovered. 
Excellent accounts of the effects of dinitro-benzol in roburite factories 
have been published by Dr Boss 1 and Professor White, 2 of Wigan. 
Mr Simeon Snell 3 has also published some most interesting cases of 
illness, cases which have been as completely investigated as possible. 
As an example of the symptoms produced, one of Mr Snell’s cases may 
be here quoted. 
C. F. W., aged 38, consulted Mr Snell for his defective sight on 
April 9, 1892. He had been a mixer at a factory for the manufacture 
of explosives. He was jaundiced, the conjunctiva yellow, and the lips 
1 Medical Chronicle, 1889, p. 89. 2 Practitioner, ii. 15, 1889. 
8 Brit. Med. Journ., March 3, 1894. 
