ARSENIC. 
§ 744-] 
565 
Salvarsan gives an orange colour and then an orange precipitate, 
on adding p-dimethyl-amino-benzaldehyde and a trace of mercuric 
chloride. Salvarsan is given by intravenous or intramuscular injections 
in doses of from 300 to 600 mgrms. Salvarsan is not stable save when 
dry ; in solution it gradually decomposes, becoming red. The early 
stages of this decomposition can be traced only by biological tests; 
the effect of the decomposition is an increase in toxic properties. 
Neo-salvarsan is sodium 3 : 3'-diamino-4 : 4'-dihydroxyarseno-benzene 
N-methylene sulphonate. Neo-salvarsan is a yellow powder dissolving 
in water to a neutral solution. The arsenical content in practice is 
lower than that of salvarsan. 
Galyl is a phosphamic acid derivative of salvarsan, 4 : 4'-dihydroxy- 
arseno-benzene-3 : 3'-phosphamic acid. Galyl is a pale yellow powder 
dissolving in carbonate of soda solution. It contains As 54*3 per cent., 
P 7-2 per cent., and has marked spirillicidal and trypanocidal properties. 
Luargol is an example of the co-ordinated compounds of aromatic 
arsenicals. The aromatic arsenicals can be combined with gold, silver, 
mercury, antimony, and'other metals; the toxic effects of the combination 
on disease-producing parasites are often in this way enhanced. The 
metallic salts in the new complex are in a non-ionic condition ; hence 
the ordinary reactions for such metals are marked. 
Luargol is a triple combination of salvarsan, silver bromide, and 
antimony ; it is 3 : 3'-diamino-4 : 4'-dihydroxyarseno-benzene-silver 
bromide-antimonyl sulphate, [Ci2H 12 0 2 N 2 As 3 ] 2 AgBr,Sb0(H 2 S0 4 ) 2 . It 
contains As 20-6 per cent., Ag 7-4 per cent., Sb 8*2 per cent. Luargol 
is dissolved in NaOH solution, 0-4 NaOH to 1-0 of luargol; it is injected 
intravenously ; ill effects are produced by subcutaneous administration. 
Ill effects following injection. —Details of no less than 9'5,000 intra¬ 
venous injections have been collated by M. Paul Ravaul, and are published 
in Archives de Med. et de Pharmacie militaire, 1916 : from which it 
appears that ill effects were rare, and that no fatal case occurred. Such 
toxic symptoms as icterus, albuminuria, or affections of the nervous 
system were noted in the following percentages of the injections : 
salvarsan, 0*025 per cent. ; neo-salvarsan, 0*051 per cent. ; galyl, 
0*113 per cent. ; luargol, 0*113 per cent. 
§ 744. Law relative to the Sale of Arsenic. —By the 14th of Viet., 
c. 12, every person selling arsenic is bound to keep a written record of 
every particular relative to each transaction, such as the name, abode, 
and calling of the purchaser, the purpose for which the poison is re¬ 
quired, and the quantity sold, etc. These particulars are to be signed 
also by the purchaser. No person (sec. 2) is allowed to sell arsenic to 
anyone unknown to the seller, unless in the presence of a witness whom 
the seller is acquainted with. The arsenic sold (sec. 3) is to be mixed 
with soot or indigo in the proportion of half an ounce of indigo to a 
