922 Wisconsin Academy of Sciences, Arts, and Letters,' 
With the introduction of the oleoresins into the United States 
Pharmacopoeia of 1860, and their extensive use in this country, 
a number of American pharmacists were lead to the conducting 
of experiments, which had for their main object the discovery of 
a solvent less expensive and less dangerous to handle than ether. 
We must, however, note that prior to this time (1860) an at¬ 
tempt was made by Berjot, a Frenchman, to use carbon disul¬ 
phide for the purpose of preparing the Extrait oleo-resineux de 
Cubehe. Garot and Schaeuffele, in 1857, in a paper on Berjot ? s 
preparation showed that nothing was gained by its use, as two 
and one-half times as much carbon disulphide as ether was re¬ 
quired to extract the drug. Furthermore, the removal of the 
last traces of this solvent was a matter of considerable difficulty. 
The solvent which first appears to have suggested itself to 
American investigators was benzin as is indicated in the publi¬ 
cations of Procter, Maish, Trimble and others. The first ac¬ 
count of its use in this connection appeared in 1866, when 
Procter published his results on the preparation of the oleoresin 
of cubeb. The following table shows the relative value of alco¬ 
hol, benzin and ether for the extraction of cubeb as found by 
Procter. 
Table 3.— Yield of oleoresin of cubeb. 
Quantity of drug 
Menstruum 
Total Yield 
grains 
1000. 
Alrohol ...................... 
grains 
250 
1000... 
Benzin........................ 
170 
1000.... 
Father....... ............._ 
219 
While Procter could find no objection to the use of alcohol as 
a solvent in the preparation of this oleoresin, he advised against 
the use of benzin as he stated that it did not extract the cubebin 
completely. 
Simultaneously with the above publication of Procter, there 
appeared an account of a general method for preparing the 
oleoresins by Eittenhouse. The latter also worked with benzin, 
but employed it as a “ follow up ’ ? solvent after percolation had 
been partially completed with ether. He also experimented 
with glycerin and fusel oil, employing them in a similar manner. 
In 1872 Maish published a review of the experiments of A, H, 
