Du Mez~The Galenical Oleoresins. 
923 
Bolton and M. Roth. The latter of these two men conducted 
an investigation on the extraction of ginger and cubebs with 
benzin, the former also included capsicum in his series of ex¬ 
periments. These workers found that ether still extracted 
some non-volatile matter after the drugs had presumably been 
exhausted with benzin. Further, that, while the benzin oleore¬ 
sins were all soluble in ether, the ethereal oleoresins of cubeb 
and ginger were only partially soluble in benzin, thus confirming 
Procter’s work in 1866 on the oleoresin of cubeb. 
Henry Trimble was the next investigator 1 ) to experiment to 
*any considerable extent with benzin as a solvent. In his re¬ 
port to the Pennsylvania Pharmaceutical Association, in 1888, 
on commercial oleoresins, he stated that while benzin was in his 
opinion preferable to concentrated ether for the extraction of 
capsicum, it would not answer for the other official oleoresins. 
Following is a table showing the comparative extractive powers 
of ether and benzin as compiled by Trimble: 
Table 4 — Relative extractive power of benzin and ether. 
Drug 1 
Yield with 
ether 
Yield with 
benzin 
Aspidium... 
Per cent. 
6.51 
19.5 
21.26 
60.59 
8.79 
3.97 
Per cent 
5.S 
18.1a 
16.65 
7.04 
2.80 
2.48 
Capsicum... 
Cubeb..... 
Lupulin..... ............. 
Pepper. 
Ginger..... 
Results similar to the above with respect to the oleoresins of 
ginger were reported by Samuel J. Riegel in 1891. 
About this time George M. Beringer became interested in the 
preparation of the oleoresins, and in 1892, he published an ac¬ 
count of his researches, in which he had employed not only 
ether and benzin as extracting menstrua, but also the heretofore 
little used solvent, acetone. With respect to benzin, he ar¬ 
rived at the same conclusions as did Trimble, viz: that its use 
1 In 1877, L. Wolff in an article entitled: The use of Petroleum Benzvnd 
in Pharmacy, stated that benzin extracted none of the pungent resin from 
ginger, no cubebic acid from cubeb, no piperin from pepper and no san¬ 
tonin or resin from wormseed. 
