928 Wisconsin Academy of Sciences , Arts, and Letters. 
sorption by the bag, 1 ) that, in operating with small quantities 
of the drug, the recovery of the remainder was scarcely worth 
the trouble. The recognition of these defects by Mohr lead 
him to construct (in 1847) a special form of apparatus for con¬ 
tinuous extraction with volatile solvents. However, while 
Mohr’s apparatus was a success from an economical standpoint, 
there is no evidence to show that it was ever employed to any 
extent by the American pharmacist, although, Procter, the 
American editor of Redwood’s translation of Mohr’s treatise 
on pharmacy, advocated its use in this connection in 1849. 
About this time (1846) Procter caused the American pharma¬ 
cists to become interested in this class of preparations by call¬ 
ing attention to his improvement upon Soubeiran’s method (as 
suggested by Dublanc) 2 * * * * * ) for preparing the Extrait oleo-resineux 
de Cubebe , a preparation similar to our present oleoresin of 
cubeb. The following is the method as devised by Procter. 
“Take cubebs, in powder, one pound avoirdupois, and sulphuric ether 
a sufficient quantity, which is two and one-half to three pounds; intro¬ 
duce the powder into a displacer, insert the lower end into a bottle that 
fits it, add the ether carefully, and cover the top of the filter with a 
piece of wet bladder through which several pin holes have been made. 8 The 
flow should be very gradual and if too rapid, the filter should be partially 
closed with a cork. By attention to this point, much less ether will be 
required. The ethereal tincture should be introduced into a large retort, 
heated by a water bath, and the receiver well refrigerated. The dis¬ 
tillation should not be hurried toward the last. When five-sixths of the 
ether have passed, it should be separated for use, and the evaporation be 
continued in the retort, observing to keep the temperature below 120°F, 
so as not to volatilize the volatile oil. ” 
A few years later (1850), this method (in essential detail) 
was given recognition by the United States Pharmacopoeia in 
connection with the preparation of the fluid extracts of cubeb 
and pepper, later known as the oleoresins of cubeb and pepper, 
respectively. For the purpose of better bringing out this 
1 Mohr, Redwood and Procter’s Pharmacy (1849), p. 268. 
2 Although Dublanc described a method for preparing the oleoresinous 
extract of cubeb, similar to that of Soubeiran, in 1828, neither method is 
given consideration here as both differed to such an extent from the usual 
procedure that they had little or no influence on the development of the 
present process. 
8 From the above description, it appears that the form of displacer used 
by Procter was the one described in Mohr, Redwood and Procter’s Phar¬ 
macy, (1849), p. 270. 
