Du Mez—The Galenical Oleoresins. 
987 
in small yellow plates melting at 184 to 185° C. It is difficulty 
soluble in water, alcohol, and ether, quite readily soluble in 
ethyl acetate. According to Boehm, 15 its constitution 16 is prob¬ 
ably represented by the following structural formula: 
h s c ch, 
Filix acid has been found to be present in the male fern 
rhizome 17 in quantities varying from 0.268 to 2.159 per cent, 
the variation in content depending principally upon the loca¬ 
tion in which the rhizomes are grown and on the time of har¬ 
vesting. 18 
phous state. Arch. f. Exp. Path. u. Pharm. (1895), p. 357. The term is now 
usually employed to designate the mixture of acid substances obtained in 
the quantitative evaluation of the oleoresin. It should not be confused 
with the Filicina of Batso, supposedly an alkaloid isolated from the ethereal 
extract. 1. c. 
15 Ann. d. Chem. (1901), 318, p. 256. 
16 The following investigators have contributed work on the constitution 
of filix acid: Luck, Ann. d. Chem. (1845), 54, p 119; Jahrb. f. prakt. 
Pharm. (1851), 22, p. 129; Grabowski, Ann. d. Chem. (1867), 143, p. 279; 
Daccomo, Ber. d. deutsch. Chem. Gesell. (1888), 21, p. 2962; Gaz. Chim. 
Ital. (1895), 24, 1, p. 511; Ibid. (1896), 26, 2, p. 441; Paterno, Ber. d. deutsch. 
Chem. Gesell. (1889), 22, p. 463; Schiff, Ann. d. Chem. (1889), 253, p. 236; 
Poulsson, Arch. f. Exp. Path. u. Pharm. (1895), 35, p. 97; Boehm, Ibid. 
(1897), 38. p. 35; Ann. d. Chem. (1898, 302, p. 171. 
17 Filix acid has also been isolated by Hausmann from Athyrium Filix 
femina Roth. Arch. d. Pharm. (1899), 237. p. 556, and has been identified 
by Bowman in Aspidium rigidum Swartz. Am. J. Pharm. (1881), 53, p. 389. 
18 Matzdorff, Apoth. Ztg. (1901), 16, p. 274. 
