Du Mez—The Galenical Oleoresins. 
989 
which may be crystallized from hot benzol or glacial acetic acid. 
The /?-form is converted into the a-modification on crystallizing 
the former from alcohol. The a-acid is thought to be the enol-, 
the /?-acid the keto-form. The structure is shown in the fol¬ 
lowing formulae: 21 
Flavaspidic acid has been isolated from the male fern rhi¬ 
zome in quantities varying from 0.10 to 0.15 per cent. 22 
Aspidinol. Aspidinol (C 12 H 16 0 4 ) crystallizes in small yel¬ 
lowish-white needles melting at 156 to 161 °C. It is difficultly 
soluble in petroleum ether and benzol, readily soluble in ether, 
alcohol, chloroform, carbon disulphide and acetone. The fol¬ 
lowing two formulae have been suggested by Boehm as repre¬ 
senting the structure of this compound : 23 
CH, 
I 
C 
CH, 
I 
C 
HOC 
HC 
V 
COCH. HOC 
OV 
COCC,H» HjCjCOC 
CH 
COH COH 
Flavaspidinin. 24: Flavaspidinin closely resembles flavaspidic 
21 Boehm, Ann. d. Chem. (1901), 318, p. 253 ; Ibid. (1903, 329, p. 310. 
21 In addition to establishing the presence of flavaspidic acid in the male 
fern rhizome, Hausmann has also isolated this compound from Athyrium 
Filix femina Roth, and Aspidium spinulo'sum Swartz. Arch. d. Fharm. (1899), 
237, p. 556. 
23 Arch. f. Exp. Path. u. Pharm. (1893), 33, p. 35; Ann. d. Chem. (1901), 
318, p. 245; Ibid. (1903), 329, p. 286. 
24 Kraft. Schweiz. Wochenschr. f. Chem. u. Pharm. (1902), 40, p. 323. 
The “phloraspin” (C 23 H 28 0 8 ) of Boehm is probably identical with flavas¬ 
pidinin. The pale yellow crystals obtained from the alcoholic solution melt 
at 211 °C, and are stated to be almost insoluble in ether, petroleum ether, 
benzene and carbon disulphide, but more readily soluble in acetone, chloro¬ 
form, hot absolute alcohol, ethyl acetate, glacial acetic acid and boiling 
xylene. Ann. d. Chem. (1903), 329, p. 338. 
