Du Mez—The Galenical Oleoresins. 
1015 
Table 30.—Continued. 
Sample 
No. 
Date 
Observer 
Source 
Crude filicin 
14. . 
1913 
Hill ... 
Not given.. 
Per cent. 
23.72 
15... . 
23.75 
16 . 
44 41 
24.50 
17 . 
44 
4 4 6 4 
24.55 
L8 . 
44 
“ “ 
25.15 
L9 . 
44 
25.27 
20.. 
44 
27.10 
21.. 
44 
27.82 
22.. 
4 * 
28.10 
23.. 
44 
“ “ 
29.75 
1. 
1914 
Linke . 
Merck & Co . 
20.40 
21.67 
27.22 
20.40 
2 . 
Brueckner, Lampe & Co. . 
Caeser & Loretz . 
3 . 
“ 
1 . 
1915 
Southall Bros. & Barclay 
Not given .... 
2 . 
21.60 
24.20 
3 . 
*• 
“ “ 
•* “ 
4 . 
“ “ “ 
.4 64 
24.60 
27.70 
5 .. 
“ 
“ “ 
“ “ 
1 . 
1916 
DuMez . 
Stearns & Co . 
7.79 ( 2 ) 
17.57 
19.04 
2. 
Lilly & Co. 
3. 
“ 
“ 
Squibb & Sons.. 
4. 
“ 
44 
Parke, Davis & Co. 
22.66 
1 These samples were adulterated with castor oil. 
2 Apparently an oleoresin from some species of fern other than Dry- 
opteris Mix mas. 
In addition to the information given in table No. 29, table 
No. 30 reveals the fact that a low filicin content in the com¬ 
mercial oleoresins is frequently due to adulteration with castor 
oil. 
Physiological Tests. 
In view of the difference in toxicity of the various constit¬ 
uents of the oleoresin with respect to the tapeworm, a physio¬ 
logical method for the evaluation of this preparation would ap¬ 
pear to be desirable. The method proposed for this purpose 
by Yagi indicates the possibilities along this line. However, 
as there is no available information regarding its application, 
aside from that given by the originator, no statement can be 
made concerning its practical value. A description of the 
method for conducting the test follows: 
Method of Yagi (1914 ): After thoroughly drying in a desiccator, ac¬ 
curately weigh 1 gram of the oleoresin and dissolve it in 25 cubic centi¬ 
meters of ether. Bring the therapeutically active constituents into 
aqueous solution by shaking the ethereal liquid with a saturated solution 
of magnesium hydroxide, using 50 cubic centimeters of the latter for every 
